公开(公告)号：US11963519B2

公开(公告)日：2024-04-23

申请号：US17895405

申请日：2022-08-25

申请人： Northwest Institute of Plateau Biology, CAS

发明人： Cen Li ,  Hongxia Yang ,  Jing Zhao ,  Lixin Wei ,  Yuzhi Du ,  Yuancan Xiao ,  Hongtao Bi ,  Zhanjuan Chen ,  Yajun Qiao ,  Jianv Wang

IPC分类号： A01K67/02 ,  C07K14/235 ,  C07K14/35

CPC分类号： A01K67/02 ,  C07K14/235 ,  C07K14/35 ,  A01K2227/105 ,  A01K2267/0356

摘要： The present disclosure provides a kit and method for constructing a long-acting depression animal model. The present disclosure adopts Bacille Calmette-Guerin (BCG) (or Mycobacterium bovis (M bovis)) and low-dose pertussis toxin (PTX) for combined induction, which greatly reduces modeling cost. A mouse model constructed by the method of the present disclosure can clearly distinguish a time interval of pathological behaviors from a time interval of depression-like behaviors and has prominent face validity and predictive validity. The method of the present disclosure is simple and convenient and does not require a large number of tedious daily operations as the depression model construction by chronic unpredictable stress, chronic restraint stress, social defeat, mother-child separation, or the like. The mouse model of the present disclosure can provide a valuable long-term intervention window for research on antidepressant therapy.

公开(公告)号：US11793177B2

公开(公告)日：2023-10-24

申请号：US16330871

申请日：2017-10-03

申请人： UNIVERSITY OF SOUTH FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE TEXAS A&M UNIVERSITY SYSTEM

发明人： Edwin John Weeber ,  David J. Segal ,  Henriette O'Geen ,  Benjamin Pyles ,  Scott V. Dindot

IPC分类号： A01K67/027 ,  C12N9/10 ,  A61K49/00

CPC分类号： A01K67/0276 ,  A01K67/027 ,  A61K49/0008 ,  C12N9/104 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/0356

摘要： The present invention concerns non-human animals with cells having a genome that is lacking the entire E3 ubiquitin ligase (Ube3a) gene (including all isoforms and alternative promoters). These animals are useful for modeling Angelman Syndrome. The invention also includes methods for assessing the effect of an agent, such as potential therapeutics, on an animal model by exposing the animal or cells, tissues, or organs isolated therefrom, to an agent of interest.

公开(公告)号：US11723347B2

公开(公告)日：2023-08-15

申请号：US16688435

申请日：2019-11-19

申请人： The Jackson Laboratory

发明人： Catherine Kaczorowski ,  Sarah M. Neuner ,  Kristen M. S. O'Connell

IPC分类号： C12N15/11 ,  A01K67/027 ,  A61P25/28 ,  C07K14/705 ,  A61K31/445 ,  C12N15/113 ,  A61K31/713

CPC分类号： A01K67/0275 ,  A61K31/445 ,  A61K31/713 ,  A61P25/28 ,  C07K14/705 ,  C12N15/1138 ,  A01K2207/15 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0318 ,  A01K2267/0356 ,  C12N2310/14

摘要： Provided herein, in some embodiments, are methods for modulating expression and/or activity of transient receptor potential cation channel subfamily C, member 3 (TRPC3), as well as methods of treating Alzheimer's disease.

公开(公告)号：US20230180718A1

公开(公告)日：2023-06-15

申请号：US17906572

申请日：2021-03-19

申请人： New York University

发明人： Dmitry RINBERG ,  Hirofumi NAKAYAMA

IPC分类号： A01K15/02

CPC分类号： A01K15/02 ,  A01K2227/105 ,  A01K2267/0356

摘要： A method of training a rodent to identify pairs of same or different odors, whereby the rodent learns the rule irrespective of the particular odors. Once trained, the rodent can be used to measure perceptual odor similarities between members of pairs of odors, which odors may be unrelated to the odors the rodent was trained on.

公开(公告)号：US09855442B2

公开(公告)日：2018-01-02

申请号：US15063296

申请日：2016-03-07

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Karl Deisseroth ,  Feng Zhang ,  Viviana Gradinaru

IPC分类号： C12N13/00 ,  A61N5/06 ,  A01K67/033 ,  A61K48/00 ,  C07K14/195 ,  C07K14/215 ,  C12N15/86 ,  C07K14/00 ,  A61K38/00

CPC分类号： A61N5/062 ,  A01K67/0333 ,  A01K2217/052 ,  A01K2227/703 ,  A01K2267/0356 ,  A61K38/00 ,  A61K48/005 ,  A61K48/0058 ,  A61K48/0083 ,  A61N5/0613 ,  A61N5/0622 ,  C07K14/00 ,  C07K14/195 ,  C07K14/215 ,  C12N13/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/16643 ,  C12N2740/16043 ,  C12N2740/16071 ,  C12N2750/14143 ,  C12N2830/002

摘要： Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).

公开(公告)号：US20170305990A1

公开(公告)日：2017-10-26

申请号：US15119583

申请日：2015-02-20

申请人： The Johns Hopkins University

发明人： Xinzhong Dong ,  Hao-Jui Weng

IPC分类号： C07K14/705 ,  A61K38/00

CPC分类号： C07K14/705 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/00 ,  A61K38/1709 ,  A61K48/00

摘要： The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.

公开(公告)号：US20170267651A1

公开(公告)日：2017-09-21

申请号：US15505898

申请日：2014-08-22

申请人： Duke University ,  The Regents of the University of California

发明人： Wolfgang LIEDTKE ,  Martin STEINHOFF ,  Farshid GUILAK

IPC分类号： C07D277/20 ,  A01K67/027 ,  G01N33/68 ,  A61K9/00 ,  C07K14/705 ,  C07D519/00 ,  A61K49/00

CPC分类号： C07D277/20 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K9/0014 ,  A61K31/426 ,  A61K31/4439 ,  A61K49/0008 ,  C07D519/00 ,  C07K14/705 ,  G01N33/6872 ,  G01N33/6881 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10

摘要： Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

公开(公告)号：US09603872B2

公开(公告)日：2017-03-28

申请号：US12598287

申请日：2008-05-02

申请人： Anne M. Cataldo ,  Peter A. Paskevich ,  Bruce M. Cohen

发明人： Anne M. Cataldo ,  Bruce M. Cohen

IPC分类号： A61K35/12 ,  A01K67/027 ,  C12N9/12 ,  G01N33/68 ,  A61K35/00

CPC分类号： A61K35/12 ,  A01K67/0271 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K9/0019 ,  A61K35/00 ,  A61K45/06 ,  C12N9/1252 ,  G01N33/6896

摘要： The invention features methods, kits, and compositions for mitochondrial replacement in the treatment of disorders arising from mitochondrial dysfunction. The invention also features methods of diagnosing neuropsychiatric (e.g., bipolar disorder) and neurodegenerative disorders based on mitochondrial structural abnormalities.

公开(公告)号：US20160346281A1

公开(公告)日：2016-12-01

申请号：US15108953

申请日：2014-12-23

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Bing YE ,  Jung Hwan KIM ,  Gabriella STERNE

IPC分类号： A61K31/506 ,  C12N15/113 ,  C12Q1/68 ,  C07K16/40

CPC分类号： A61K31/506 ,  A01K67/0339 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2227/706 ,  A01K2267/0356 ,  A61K31/496 ,  A61K31/5025 ,  C07K16/40 ,  C07K2317/76 ,  C12N15/1137 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/158

摘要： Provided herein is technology relating to treatment of neurological disorders and particularly, but not exclusively, to methods and compositions for treating neurological disorders caused by aberrant and/or dysregulated expression and/or activity of Down syndrome cell adhesion molecule (Dscam) with agents that modulate physiological components associated with the functions and/or dysfunctions of Dscam, e.g., physiological components that can be modulated to counteract aberrant Dscam expression and/or activity such as Abelson murine leukemia viral oncogene homolog 1 kinase.

摘要翻译： 本文提供了涉及神经障碍治疗的技术，特别但并非排他地涉及用于治疗由唐氏综合征细胞粘附分子（Dscam）的异常和/或失调的表达和/或活性引起的神经系统疾病的方法和组合物，所述药剂可调节 与Dscam的功能和/或功能障碍相关的生理成分，例如可被调节以抵抗异常Dscam表达和/或活性的生理成分，例如Abelson鼠白血病病毒癌基因同系物1激酶。

公开(公告)号：US09457103B2

公开(公告)日：2016-10-04

申请号：US14156133

申请日：2014-01-15

申请人： The Regents of the University of California

发明人： David V. Schaffer ,  Ryan R. Klimczak ,  James T. Koerber ,  John G. Flannery

IPC分类号： A61K39/23 ,  A61K48/00 ,  A01K67/027 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  A61K38/17 ,  A61K38/18 ,  A61K35/76 ,  A61K38/00

CPC分类号： C12N7/00 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K9/0048 ,  A61K35/76 ,  A61K38/00 ,  A61K38/179 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/185 ,  A61K48/0008 ,  A61K48/0075 ,  C07K14/005 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14142 ,  C12N2750/14145 ,  C12N2810/855

摘要： The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.

摘要翻译： 本公开提供具有改变的衣壳蛋白的腺相关病毒（AAV）病毒颗粒，其中与野生型AAV相比，AAV病毒体显示更大的视网膜细胞感染性。 本公开进一步提供将基因产物递送至个体中的视网膜细胞的方法以及治疗眼部疾病的方法。