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    Compounds useful for modulating abnormal cell proliferation
    1.
    发明授权
    Compounds useful for modulating abnormal cell proliferation 有权
    可用于调节异常细胞增殖的化合物

    公开(公告)号：US07202383B2

    公开(公告)日：2007-04-10

    申请号：US10940010

    申请日：2004-09-14

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    IPC分类号： C07C233/09 ,  A61K31/165

    CPC分类号： C07C235/34

    摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1–4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述了式I的化合物及其盐，溶剂化物和水合物：

    Novel compounds useful for modulating abnormal cell proliferation
    3.
    发明申请
    Novel compounds useful for modulating abnormal cell proliferation 失效
    用于调节异常细胞增殖的新型化合物

    公开(公告)号：US20070185123A1

    公开(公告)日：2007-08-09

    申请号：US11723261

    申请日：2007-03-19

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    IPC分类号： A61K31/4965 ,  A61K31/505 ,  A61K31/44 ,  A61K31/165 ,  A61K31/405 ,  A61K31/4172 ,  A61K31/381 ,  A61K31/34

    CPC分类号： C07C235/34

    摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述式I化合物及其盐，溶剂合物和水合物：其中：R 1，R 2和R 3各自独立地为 选自OH，C 1-6烷基，OC 1-6烷基，OC（O）C 1-6烷基，C（O ）C 1-6烷基，NH 2，NH-C 1-6烷基，N（C 1-6）烷基， C（O）NHC 1-6烷基，C（O）N（C 1-6）烷基）（C 1-6烷基） 烷基）（C 1-6烷基），SH，SC 1-6烷基，NO 2，CF 3 OCF 3和卤素; 并且Ar是选自苯，萘，喹啉，异喹啉，吲哚，吡啶，吡嗪，嘧啶，咪唑，呋喃和噻吩的芳族或杂芳族基团，未取代或被1-4个独立地选自OH，C 1 C 1-6烷基，C 1-6烷氧基，C 1-3亚烷基二氧基，NH 2 N，NH- 1-6烷基，N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6， 烷基，NO 2，CF 3，OCF 3和卤素。 式I的化合物可用于治疗方法和用于调节细胞增殖的组合物，在诊断测定和研究工具中。

    Compounds useful for modulating abnormal cell proliferation
    6.
    发明授权
    Compounds useful for modulating abnormal cell proliferation 失效
    可用于调节异常细胞增殖的化合物

    公开(公告)号：US07407989B2

    公开(公告)日：2008-08-05

    申请号：US11723261

    申请日：2007-03-19

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    IPC分类号： A61K31/65

    CPC分类号： C07C235/34

    摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述式I化合物及其盐，溶剂合物和水合物：其中：R 1，R 2和R 3各自独立地为 选自OH，C 1-6烷基，OC 1-6烷基，OC（O）C 1-6烷基，C（O ）C 1-6烷基，NH 2，NH-C 1-6烷基，N（C 1-6）烷基， C（O）NHC 1-6烷基，C（O）N（C 1-6）烷基）（C 1-6烷基） 烷基）（C 1-6烷基），SH，SC 1-6烷基，NO 2，CF 3 OCF 3和卤素; 并且Ar是选自苯，萘，喹啉，异喹啉，吲哚，吡啶，吡嗪，嘧啶，咪唑，呋喃和噻吩的芳族或杂芳族基团，未取代或被1-4个独立地选自OH，C 1 C 1-6烷基，C 1-6烷氧基，C 1-3亚烷基二氧基，NH 2 N，NH- 1-6烷基，N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6， 烷基，NO 2，CF 3，OCF 3和卤素。 式I的化合物可用于治疗方法和用于调节细胞增殖的组合物，在诊断测定和研究工具中。

    Novel compounds useful for modulating abnormal cell proliferation
    7.
    发明申请
    Novel compounds useful for modulating abnormal cell proliferation 有权
    用于调节异常细胞增殖的新型化合物

    公开(公告)号：US20060058554A1

    公开(公告)日：2006-03-16

    申请号：US10940010

    申请日：2004-09-14

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    IPC分类号： C07C235/42

    CPC分类号： C07C235/34

    摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH-C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述了式I的化合物及其盐，溶剂化物和水合物：

    Compounds for modulating cell proliferation
    9.
    发明申请
    Compounds for modulating cell proliferation 审中-公开
    用于调节细胞增殖的化合物

    公开(公告)号：US20070197660A1

    公开(公告)日：2007-08-23

    申请号：US10566815

    申请日：2004-07-30

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Thomas Grunberger ,  Octavian Cimpean

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Thomas Grunberger ,  Octavian Cimpean

    IPC分类号： A61K31/135

    CPC分类号： A61K31/4402 ,  C07C255/41 ,  C07C323/46 ,  C07D213/71

    摘要： Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—(C1-6alkyl), N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n=1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.

    摘要翻译： 具有式（I）或（III）的化合物，其中R 1，R 2和R 3各自独立地选自H，OH， C 1-6烷基，C 1-6烷氧基，NH 2，NH-（C 1-6）烷基， 烷基），N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6烷基， CH 2，CF 3，OCF 3 N和卤素; R 4是未取代的Ar或Ar，其被1-4个独立地选自C 1-6 - 烷基，C 1-6 - 烷氧基和卤代 ; X选自（CH 2 CH 2 CH 2）n和（CH）n N，且n = 1 -4，其盐，溶剂化物和水合物，可用于调节或抑制细胞增殖。