公开(公告)号：US20100113940A1

公开(公告)日：2010-05-06

申请号：US12615950

申请日：2009-11-10

申请人： Chandan K. Sen ,  Ronald X. Xu

发明人： Chandan K. Sen ,  Ronald X. Xu

IPC分类号： A61B6/00

CPC分类号： G01N21/6456 ,  A61B5/0062 ,  A61B5/14551 ,  A61B5/14558 ,  A61B5/445 ,  A61B5/6814 ,  A61B5/742 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6423

摘要： Appropriate assessment of wound oxygenation is critical to establish a diagnosis, to monitor the effect of the treatment, to guide the therapeutic process, to identify the presence of infection, and to predict the treatment outcome. Embodied systems and methods represent an enabling technology for noninvasive and objective assessment of wound tissue oxygenation. In addition to wound healing, disclosed embodiments offer low cost and portable avenues for noninvasive assessment of multiple clinical parameters for the detection and intervention of various malignancies in multiple soft tissue systems.

摘要翻译： 对伤口充氧的适当评估对于建立诊断，监测治疗的效果，指导治疗过程，确定感染的存在以及预测治疗结果至关重要。 实体系统和方法代表了创伤组织氧合无创和客观评估的有效技术。 除了伤口愈合之外，所公开的实施例提供了用于非侵入性评估多个临床参数的低成本和便携式通道，用于多个软组织系统中各种恶性肿瘤的检测和干预。

公开(公告)号：US20090234225A1

公开(公告)日：2009-09-17

申请号：US12352408

申请日：2009-01-12

申请人： Edward W. Martin ,  Ronald X. Xu ,  Duxin Sun ,  Stephen P. Povoski ,  Joseph Pierre Heremans ,  Robert Lee ,  Vish V. Subramaniam ,  Claudia Turro

发明人： Edward W. Martin ,  Ronald X. Xu ,  Duxin Sun ,  Stephen P. Povoski ,  Joseph Pierre Heremans ,  Robert Lee ,  Vish V. Subramaniam ,  Claudia Turro

IPC分类号： A61B6/00 ,  A61K49/00

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N33/57469 ,  G01N33/582

摘要： Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent.

摘要翻译： 示例性实施方案包括用于目标组织的术中检测的系统，方法和组合物。 至少一个实施方案包括可用于术中检测荧光靶向剂，其结合位点及其在癌组织内的相互作用的荧光检测仪器。 一个示例性实施方案即使在低浓度下也对荧光剂的局部沉积高度敏感。 在至少一个实施例中，该系统包括可用于实时地激发，检测和报告靶向剂的荧光沉积的手持式导航仪器。 在替代实施例中，系统包括可佩戴单元，以激发，检测和视觉报告目标剂对用户的荧光沉积。 可穿戴单元包括允许用户基于荧光靶向剂的近实时荧光检测来执行图像引导手术的眼镜。