公开(公告)号：US20100113610A1

公开(公告)日：2010-05-06

申请号：US12609918

申请日：2009-10-30

申请人： Chang H. Kim ,  Hyung W. Lim ,  Seung G. Kang

发明人： Chang H. Kim ,  Hyung W. Lim ,  Seung G. Kang

IPC分类号： A61K31/07 ,  C12N5/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： A61K31/07

摘要： The present invention provides methods for generating mucosal tissue homing immunosuppressive T-cells comprising treating naïve T-cells with retinoids and/or retinoid agonists. Methods are also provided for treating a mammal having an inflammatory or immunological disease by administering a therapeutically effective dose of retinoids and/or retinoid agonists. Additional methods are also provided for boosting the immune system of a mammal by inhibiting the generation of immunosuppressive T-cells by administering a therapeutically effective dose of a retinoid receptor antagonist to the mammal.

摘要翻译： 本发明提供了产生粘膜组织归巢免疫抑制性T细胞的方法，包括用类维生素A和/或类视色素激动剂处理初始T细胞。 还提供了通过施用治疗有效剂量的类视色素和/或类视色素激动剂来治疗具有炎症或免疫疾病的哺乳动物的方法。 还提供了另外的方法用于通过向哺乳动物施用治疗有效剂量的类视黄醇受体拮抗剂来抑制免疫抑制性T细胞的产生来增强哺乳动物的免疫系统。