公开(公告)号：US20130171278A1

公开(公告)日：2013-07-04

申请号：US13822714

申请日：2011-09-16

申请人： Chang-Ho Lee ,  In-Ho Kim ,  Dae Seok Han ,  Young-Eon Kim ,  Dong-Jun Park ,  Jun-Hyeok Choi ,  Hye-Sung Lee ,  Sueong-Mock Cho

发明人： Chang-Ho Lee ,  In-Ho Kim ,  Dae Seok Han ,  Young-Eon Kim ,  Dong-Jun Park ,  Jun-Hyeok Choi ,  Hye-Sung Lee ,  Sueong-Mock Cho

IPC分类号： A61K36/23 ,  A61K36/31 ,  A61K36/79

CPC分类号： A61K36/23 ,  A61K36/282 ,  A61K36/31 ,  A61K36/57 ,  A61K36/79 ,  A61K2300/00

摘要： The present invention relates to a composition for promoting memory or learning ability and to a composition for preventing and treating cognitive impairment, which comprise one, two or more plant extracts selected from the group consisting of Artemisia apiaceae extract, Illicium verum extract and Lepidium apefalum extract. The present invention has the effect of inhibiting neural cell damage, especially, neural cells of the basal part of the cerebrum by inhibiting acetylcholinesterase activity and through antioxidative activity (for example, inhibiting the generation of oxidative reactive species) and affinity for an NMDA receptor. The compositions of the present invention may have the effect of not only promoting memory or learning ability by protecting neural cells and preventing damage to neural cells but also of preventing and treating diseases caused by cognitive impairment. In addition, according to the present invention, Lepidium apefalum extract is provided as basic substance for pharmaceuticals or food which has efficacy in promoting memory or learning ability or efficacy for preventing and treating cognitive impairment.

摘要翻译： 本发明涉及用于促进记忆或学习能力的组合物和用于预防和治疗认知障碍的组合物，其包含一种，两种或更多种选自蒿科蒿提取物，ium藜提取物和韭菜提取物的植物提取物 。 本发明通过抑制乙酰胆碱酯酶活性和通过抗氧化活性（例如，抑制氧化反应物质的产生）和对NMDA受体的亲和力，具有抑制神经细胞损伤，特别是抑制大脑基底部分的神经细胞的作用。 本发明的组合物可以具有不仅通过保护神经细胞并防止对神经细胞的损伤而且通过预防和治疗由认知障碍引起的疾病而促进记忆或学习能力的效果。 此外，根据本发明，提供了作为用于促进记忆或学习能力或预防和治疗认知功能障碍的功效的药物或食品的碱性物质。