Monoclonal Antibody to Human TGF-Beta Induced Gene-H3 and Use Thereof
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    发明申请
    Monoclonal Antibody to Human TGF-Beta Induced Gene-H3 and Use Thereof 审中-公开
    人TGF-β诱导的基因H3的单克隆抗体及其用途

    公开(公告)号:US20090068189A1

    公开(公告)日:2009-03-12

    申请号:US11791043

    申请日:2005-11-18

    CPC分类号: C07K16/18 C07K2317/76

    摘要: The present invention relates to a monoclonal antibody to human βig-h3 and the use thereof. More particularly, it relates to a monoclonal antibody to the human βig-h3 protein, wherein the epitope of the monoclonal antibody is the H1 region of the fourth fas-1 domain of the human βig-h3 protein. The monoclonal antibody can specifically recognize the human βig-h3 protein in tissue, and so will be useful in diagnosing a disease associated with the increase or decrease of the βig-h3 protein. In addition, the monoclonal antibody has the effect of inhibiting the cell adhesion activity of the βig-h3 protein.

    摘要翻译: 本发明涉及对人β-h3的单克隆抗体及其用途。 更具体地说,本发明涉及对人β-h3蛋白的单克隆抗体,其中单克隆抗体的表位是人β-h3蛋白的第四个fas-1结构域的H1区。 单克隆抗体可以特异性识别组织中的人βIG-h3蛋白,因此可用于诊断与βig-h3蛋白的增加或减少相关的疾病。 此外,单克隆抗体具有抑制β-h3蛋白的细胞粘附活性的作用。