公开(公告)号：US08652537B2

公开(公告)日：2014-02-18

申请号：US13400784

申请日：2012-02-21

申请人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

发明人： Chang-Kyun Han ,  Wie-Jong Kwak ,  Ki Won Joung ,  Hun Seung Yoo ,  Do Seung Kum ,  Yong-Baik Cho ,  Keun Ho Ryu ,  Hae In Rhee ,  Taek Su Kim ,  In Ho Jung ,  So Yoon Lee ,  Jung Bum Yi ,  Joo Hyon Kim ,  Key An Um

IPC分类号： A61K36/00

CPC分类号： A61K36/536 ,  A61K36/428 ,  A61K36/716 ,  A61K2300/00

摘要： The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

摘要翻译： 本发明涉及一种用于软骨保护的草药组合物，其包括铁线莲（Trichosanthis Radix），夏枯草（Prunellae Spica）的植物提取物和迷迭香酸的最佳含量，以：（i）缓解疼痛; （ii）抑制急性/慢性炎症，血小板/全血聚集，免疫细胞（B淋巴细胞和T淋巴细胞）增殖，炎症诱导酶活性和与关节组织降解相关的酶活性; （iii）有毒活性氧自由基的清除活性; 和（iv）进一步提供优异的软骨保护活性，有效地用作镇痛作用的抗炎药，血液循环增强剂，关节炎治疗剂和软骨保护。