APPLICATION OF 20(S)-PROTOPANAXADIOL IN PREPARATION OF ANTIDEPRESSANTS
    2.
    发明申请
    APPLICATION OF 20(S)-PROTOPANAXADIOL IN PREPARATION OF ANTIDEPRESSANTS 审中-公开
    20(S)-PROPOPANAXADIOL在制备抗生素中的应用

    公开(公告)号:US20120214779A1

    公开(公告)日:2012-08-23

    申请号:US13404014

    申请日:2012-02-24

    IPC分类号: A61K31/56 A61P25/24

    CPC分类号: A61K31/575

    摘要: The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated that the compound could remarkably increase the level of NE, 5-HT and HAV in the brains of model rats having depressive disorders, remarkably enhance tremors induced by 5-hydroxytryptophan (5-HTP) and behavioral effects induced by levodopa, and inhibit the re-uptake of 5-HT and NA.

    摘要翻译: 本发明提供了20(S) - 原人参二醇在制备用于治疗抑郁精神障碍的药物中的新用途。 药理试验结果表明,该化合物可显着增加患有抑郁障碍的模型大鼠脑中NE,5-HT和HAV水平,显着增强5-羟色氨酸诱发的震颤(5-HTP)和左旋多巴诱导的行为效应 ,并抑制5-HT和NA的再摄取。

    USE OF 20(S)-PROTOPANAXADIOL IN MANUFACTURE OF ANTIDEPRESSANTS
    3.
    发明申请
    USE OF 20(S)-PROTOPANAXADIOL IN MANUFACTURE OF ANTIDEPRESSANTS 有权
    20(S)-PROPOPANAXADIOL在抗生素制造中的应用

    公开(公告)号:US20100234624A1

    公开(公告)日:2010-09-16

    申请号:US12304114

    申请日:2007-06-08

    IPC分类号: C07J9/00

    CPC分类号: A61K31/575

    摘要: The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated that the compound could remarkably increase the level of NE, 5-HT and HAV in the brains of model rats having depressive disorders, remarkably enhance tremors induced by 5-hydroxytryptophan (5-HTP) and behavioral effects induced by levodopa, and inhibit the re-uptake of 5-HT and NA.

    摘要翻译: 本发明提供了20(S) - 原人参二醇在制备用于治疗抑郁精神障碍的药物中的新用途。 药理试验结果表明,该化合物可显着增加患有抑郁障碍的模型大鼠脑中NE,5-HT和HAV水平,显着增强5-羟色氨酸诱发的震颤(5-HTP)和左旋多巴诱导的行为效应 ,并抑制5-HT和NA的再摄取。

    Use of 20(S)-protopanaxadiol in manufacture of antidepressants
    4.
    发明授权
    Use of 20(S)-protopanaxadiol in manufacture of antidepressants 有权
    使用20(S) - 原人参二醇制造抗抑郁药

    公开(公告)号:US08148354B2

    公开(公告)日:2012-04-03

    申请号:US12304114

    申请日:2007-06-08

    IPC分类号: A61K31/56 C07J9/00

    CPC分类号: A61K31/575

    摘要: The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated that the compound could remarkably increase the level of NE, 5-HT and HAV in the brains of model rats having depressive disorders, remarkably enhance tremors induced by 5-hydroxytryptophan (5-HTP) and behavioral effects induced by levodopa, and inhibit the re-uptake of 5-HT and NA.

    摘要翻译: 本发明提供了20(S) - 原人参二醇在制备用于治疗抑郁精神障碍的药物中的新用途。 药理试验结果表明,该化合物可显着增加患有抑郁障碍的模型大鼠脑中NE,5-HT和HAV水平,显着增强5-羟色氨酸诱发的震颤(5-HTP)和左旋多巴诱导的行为效应 ,并抑制5-HT和NA的再摄取。