公开(公告)号：US20140248363A1

公开(公告)日：2014-09-04

申请号：US14200292

申请日：2014-03-07

申请人： Charite-Universitatsmedizin Berlin

发明人： Susanne WAGNER ,  Matthias TAUPITZ ,  Eyk SCHELLENBERGER ,  Jorg SCHNORR ,  Monika EBERT ,  Gesche GENTER ,  Harald KRATZ

IPC分类号： A61K9/51 ,  A61K31/375 ,  A61K45/06 ,  A61K33/26

摘要： The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.

摘要翻译： 本发明涉及基于磁赤铁矿或磁赤铁矿/磁铁矿的磷酸盐吸附剂，其包含（i）包含反尖晶石氧化铁晶体结构的氧化铁芯，（ii）选自单体碳水化合物，特别是单糖或二糖的涂层 ，糖醇或其混合物，和/或（iii）选自聚合碳水化合物的药物赋形剂，其中磷酸盐吸附剂具有尺寸小于20nm的氧化铁核心（i）的纳米颗粒的形式。 本发明还涉及基于磁赤铁矿或磁赤铁矿/磁铁矿生产磷酸盐吸附剂的方法，包括磷酸盐吸附剂的药物组合物及其医疗用途，特别是用于预防和/或治疗高磷酸血症。