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15 条记录 (耗时 0.015 秒)

    NANOPARTICULATE PHOSPHATE ADSORBENT ON THE BASIS OF MAGHEMITE OR MAGHEMITE/MAGNETITE, PRODUCTION AND USES THEREOF
    5.
    发明申请
    NANOPARTICULATE PHOSPHATE ADSORBENT ON THE BASIS OF MAGHEMITE OR MAGHEMITE/MAGNETITE, PRODUCTION AND USES THEREOF 审中-公开
    基于镁或镁/镁的纳米磷酸盐吸附剂，其生产及其用途

    公开(公告)号：US20140248363A1

    公开(公告)日：2014-09-04

    申请号：US14200292

    申请日：2014-03-07

    申请人： Charite-Universitatsmedizin Berlin

    发明人： Susanne WAGNER ,  Matthias TAUPITZ ,  Eyk SCHELLENBERGER ,  Jorg SCHNORR ,  Monika EBERT ,  Gesche GENTER ,  Harald KRATZ

    IPC分类号： A61K9/51 ,  A61K31/375 ,  A61K45/06 ,  A61K33/26

    摘要： The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.

    摘要翻译： 本发明涉及基于磁赤铁矿或磁赤铁矿/磁铁矿的磷酸盐吸附剂，其包含（i）包含反尖晶石氧化铁晶体结构的氧化铁芯，（ii）选自单体碳水化合物，特别是单糖或二糖的涂层 ，糖醇或其混合物，和/或（iii）选自聚合碳水化合物的药物赋形剂，其中磷酸盐吸附剂具有尺寸小于20nm的氧化铁核心（i）的纳米颗粒的形式。 本发明还涉及基于磁赤铁矿或磁赤铁矿/磁铁矿生产磷酸盐吸附剂的方法，包括磷酸盐吸附剂的药物组合物及其医疗用途，特别是用于预防和/或治疗高磷酸血症。

    MC4R Agonist Efficacy in Subjects with MC4R Deficiencies and Impaired NFAT Signaling
    6.
    发明申请
    MC4R Agonist Efficacy in Subjects with MC4R Deficiencies and Impaired NFAT Signaling 有权

    公开(公告)号：US20210052551A1

    公开(公告)日：2021-02-25

    申请号：US16971377

    申请日：2019-02-20

    申请人： Charite - Universitatsmedizin Berlin

    发明人： Peter Kuhnen ,  Heike Biebermann ,  Heiko Krude

    IPC分类号： A61K31/404 ,  C12Q1/6869

    摘要： The invention relates to a Melanocortin-4 receptor (MC4R) agonist that exhibits greater induction of NFAT signaling compared to α-MSH for use in the treatment and/or prevention of a medical condition associated with MC4R deficiency in a subject having an MC4R deficiency associated with impaired Nuclear factor of activated T-cells (NFAT) signaling. The present invention further relates to an in vitro method for the diagnosis, prognosis and/or assessment of likelihood of whether a subject with, or at risk of having and/or developing, a medical condition associated with MC4R deficiency, will respond to treatment with an MC4R agonist that exhibits greater induction of NFAT signaling compared to α-MSH, the method comprising (i) providing a sample from said subject, and (ii) determining whether the subject has an MC4R deficiency associated with impaired NFAT signaling by assessing said sample, (iii) wherein the presence of an MC4R deficiency associated with impaired NFAT signaling is indicative that treatment with an MC4R agonist that exhibits greater induction of NFAT signaling compared to α-MSH will be effective in said subject.

    USE OF AN ANG-(1-7) RECEPTOR AGONIST IN ACUTE LUNG INJURY
    8.
    发明申请
    USE OF AN ANG-(1-7) RECEPTOR AGONIST IN ACUTE LUNG INJURY 审中-公开
    ANG-（1-7）受体激动剂在急性肺损伤中的应用

    公开(公告)号：US20160051621A1

    公开(公告)日：2016-02-25

    申请号：US14750500

    申请日：2015-06-25

    申请人： Charite-Universitatsmedizin Berlin

    发明人： Thomas Walther ,  Wolfgang Kuebler

    IPC分类号： A61K38/08

    CPC分类号： A61K38/085 ,  A61K31/4178 ,  C07D409/10 ,  C07K7/14

    摘要： The present invention refers to a peptidic or non-peptidic angiotensin(1-7) (Ang-(1-7)) receptor agonist, preferably a Mas receptor agonist, for the prevention and/or treatment of acute lung injury, preferably acute respiratory distress syndrome.

    摘要翻译： 本发明涉及用于预防和/或治疗急性肺损伤的肽或非肽血管紧张素（1-7）（Ang-（1-7））受体激动剂，优选Mas受体激动剂，优选急性呼吸 遇险综合征

    METHOD FOR DETERMINING DERMATOPHYTES
    9.
    发明申请
    METHOD FOR DETERMINING DERMATOPHYTES 有权

    公开(公告)号：US20210087641A1

    公开(公告)日：2021-03-25

    申请号：US16971163

    申请日：2019-02-19

    申请人： CHARITE - UNIVERSITATSMEDIZIN BERLIN

    发明人： Christiane KUPSCH ,  Yvonne GRASER

    IPC分类号： C12Q1/6895

    摘要： The invention relates to methods assessing nucleic acids encoding a dermatophyte extracellular serine/threonine-rich protein (ESTRP gene) in identifying and preferably differentiating between dermatophytes. The invention relates further to corresponding detection kits, in addition to isolated probes and oligonucleotides.