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12 条记录 (耗时 0.036 秒)

    Cyclodextrin solubilizers for liquid and semi-solid formulations
    2.
    发明申请
    Cyclodextrin solubilizers for liquid and semi-solid formulations 审中-公开
    用于液体和半固体制剂的环糊精增溶剂

    公开(公告)号：US20060105045A1

    公开(公告)日：2006-05-18

    申请号：US11268630

    申请日：2005-11-08

    申请人： Charles Buchanan ,  Norma Buchanan ,  Juanelle Lambert ,  Jessica Posey-Dowty

    发明人： Charles Buchanan ,  Norma Buchanan ,  Juanelle Lambert ,  Jessica Posey-Dowty

    IPC分类号： A61K31/724 ,  A61K9/14

    CPC分类号： A61K9/4866 ,  A61K9/4858 ,  A61K31/724 ,  A61K47/10 ,  A61K47/40

    摘要： This invention is directed to compositions comprising a water-miscible organic solvent or solvent mixture and one or more cyclodextrin derivatives soluble in the organic water-miscible organic solvent or solvent mixture. In some embodiments, the composition comprises one or more compounds. The invention is further directed to capsules containing the compositions of the present invention and the administration of pharmaceutically active compounds or molecules to subjects. The invention also includes methods of enhancing the solubility of a compound comprising forming a complex or mixture of a compound with a hydroxybutenyl cyclodextrin and a water-miscible solvent.

    摘要翻译： 本发明涉及包含水混溶性有机溶剂或溶剂混合物和一种或多种可溶于有机水混溶性有机溶剂或溶剂混合物的环糊精衍生物的组合物。 在一些实施方案中，组合物包含一种或多种化合物。 本发明还涉及含有本发明组合物和向受试者施用药物活性化合物或分子的胶囊。 本发明还包括提高包括形成化合物与羟基丁烯基环糊精和水混溶性溶剂的络合物或混合物的化合物的溶解度的方法。

    Microfluidic apparatus and method for synthesis of molecular imaging probes
    7.
    发明申请
    Microfluidic apparatus and method for synthesis of molecular imaging probes 审中-公开
    用于合成分子成像探针的微流控装置和方法

    公开(公告)号：US20050232387A1

    公开(公告)日：2005-10-20

    申请号：US10827893

    申请日：2004-04-20

    申请人： Henry Padgett ,  Charles Buchanan ,  Thomas Collier ,  Joseph Matteo ,  Charles Alvord

    发明人： Henry Padgett ,  Charles Buchanan ,  Thomas Collier ,  Joseph Matteo ,  Charles Alvord

    IPC分类号： A61M36/14

    CPC分类号： A61K51/0491

    摘要： The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment. The method for synthesizing a radiochemical in a microfluidic environment comprises: i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port; ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor; iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor; v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, the reacting step resulting in formation of a radiochemical; and vi) collecting the radiochemical from the outlet port of the micro reactor.

    摘要翻译： 本发明提供了一种用于制备放射化学物质的方法和装置，例如PET分子成像探针，其中将放射性同位素与有机或无机化合物偶联以形成正电子发射分子成像探针的反应步骤或步骤在微流体 环境。 用于在微流体环境中合成放射化学的方法包括：i）提供微反应器，其包括与第一和第二入口端口流体连通的第一入口端口，第二入口端口，出口端口和至少一个微通道， 出口口 ii）将反应性前体引入微反应器的第一入口，反应性前体适于与放射性同位素反应以形成放射化学物质; iii）将包含放射性同位素的溶液引入微反应器的第二入口; iv）使反应性前体与微反应器的微通道中的含同位素溶液接触; v）使反应性前体与含有同位素的溶液反应，作为反应性前体，并且含同位素的溶液流过微反应器的微通道，反应步骤导致形成放射化学; 和vi）从微反应器的出口收集放射化学物质。

    Inflatable lumbar support cushion for seats
    9.
    发明授权
    Inflatable lumbar support cushion for seats 有权

    公开(公告)号：US11871852B1

    公开(公告)日：2024-01-16

    申请号：US17902424

    申请日：2022-09-02

    申请人： Charles Buchanan ,  Christine Riley

    发明人： Charles Buchanan ,  Christine Riley

    IPC分类号： B60N2/60 ,  A47C7/46 ,  B60N2/02 ,  B60N2/64 ,  B60N2/66

    CPC分类号： A47C7/467 ,  B60N2/0224 ,  B60N2/643 ,  B60N2/646 ,  B60N2/663 ,  B60N2/665

    摘要： An inflatable lumbar support cushion for seats including a seat cushion assembly connected with an air bladder that has a hollow body and is covered by a lumbar support that is hollow. The air bladder is inflated by a pump unit assembly which includes a pump unit that blows air to the air bladder by an air hose adapting the size of the lumbar support as required and defining a lumbar support portion which provides comfort to a user. The air bladder configured as a cushion for a sofa. The pump unit can be electronic or manual. The seat cushion can be adapted to different seats by an attaching base located to a bottom surface thereof and the lumbar support may be attached to a backrest by a strap allowing to fasten the inflatable lumbar support cushion to any suitable seat.

    Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG
    10.
    发明申请
    Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG 审中-公开
    用于合成包括FDG的分子成像探针的微流体装置和方法

    公开(公告)号：US20050232861A1

    公开(公告)日：2005-10-20

    申请号：US10827992

    申请日：2004-04-20

    申请人： Charles Buchanan ,  Henry Padgett ,  Thomas Collier

    发明人： Charles Buchanan ,  Henry Padgett ,  Thomas Collier

    IPC分类号： A61K51/00 ,  C07B59/00 ,  C07F5/00

    CPC分类号： C07B59/00 ,  A61K51/0491 ,  C07B59/005 ,  C07B2200/05

    摘要： The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises: providing a micro reactor; introducing a liquid reactive precursor dissolved in a polar aprotic solvent into an inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; introducing a solution comprising a radioactive isotope dissolved in a polar aprotic solvent into another inlet port of the micro reactor; contacting the reactive precursor with the isotope-containing solution in a microchannel of the micro reactor; reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, wherein the reacting step is conducted at a temperature above the boiling point of the polar aprotic solvent at 1 atm and at a pressure sufficient to maintain the polar aprotic solvent in liquid form; and collecting the resulting radiochemical from the micro reactor.

    摘要翻译： 本发明提供了一种用于制备放射化学物质的方法和装置，其中在微流体环境中进行将放射性同位素与反应性前体耦合以形成正电子发射分子成像探针的反应。 该方法包括：提供微反应器; 将溶解在极性非质子溶剂中的液体反应性前体引入微反应器的入口端口，所述反应性前体适于与放射性同位素反应以形成放射化学物质; 将包含溶解在极性非质子溶剂中的放射性同位素的溶液引入微反应器的另一入口; 在微反应器的微通道中使反应性前体与含同位素的溶液接触; 使反应性前体与含有同位素的溶液反应，作为反应性前体，同位素溶液流过微反应器的微通道，其中反应步骤在高于大气压极性非质子传递溶剂沸点的温度下进行， 在足以保持极性非质子溶剂为液体形式的压力下; 并从微反应器收集所得的放射化学物质。