公开(公告)号：US06194560B1

公开(公告)日：2001-02-27

申请号：US09191852

申请日：1998-11-12

申请人： Charles J. Arntzen ,  Hugh S. Mason ,  Tariq A. Haq

发明人： Charles J. Arntzen ,  Hugh S. Mason ,  Tariq A. Haq

IPC分类号： A61K39108

CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K14/245 ,  C12N15/8258 ,  C12N2770/16022 ,  Y02A50/472

摘要： The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.

摘要翻译： 本发明的口服疫苗和口服疫苗佐剂在转基因植物中生产，然后通过消耗转基因植物来施用。 构建天然和合成编码免疫原性试剂表达的DNA序列，其在饲喂可食用植物，植物组织或衍生植物材料时能够在动物中引起免疫应答，植物转化以在植物细胞中稳定或短暂表达。 本发明提供了用于通过转基因植物免疫动物的第一已知功能方法，其中当将表达抗原的转基因植物材料供给动物时，植物表达作为免疫原和佐剂的细菌抗原。

公开(公告)号：US20070224676A1

公开(公告)日：2007-09-27

申请号：US11688491

申请日：2007-03-20

申请人： Tariq A. Haq

发明人： Tariq A. Haq

IPC分类号： C12M1/24

CPC分类号： C12M23/26 ,  C12M23/08 ,  C12M27/12 ,  C12M27/20 ,  C12M41/44

摘要： The present invention provides a roller bottle for cell growth culturing, the roller bottle including a bottom wall; a top wall having an opening formed therethrough; and, a side wall extending between the top and bottom walls, a plurality of corrugations being defined in the side wall. Further, a distance is defined between the top and bottom walls, and the corrugations are selectively deformable to alter the distance. Advantageously, with the present invention, a single roller bottle may be provided with its length being adjustable in response to cell culture size and density.

摘要翻译： 本发明提供一种用于细胞生长培养的滚瓶，所述滚瓶包括底壁; 顶壁，其具有通过其形成的开口; 以及在顶壁和底壁之间延伸的侧壁，在侧壁中限定多个波纹。 此外，在顶壁和底壁之间限定距离，并且波纹可选择性地变形以改变距离。 有利地，通过本发明，可以提供单个辊瓶，其长度可响应于细胞培养物的尺寸和密度而调节。