公开(公告)号：US20090170930A1

公开(公告)日：2009-07-02

申请号：US12400756

申请日：2009-03-09

申请人： Cheng HE ,  Weidong ZHANG ,  Xiaohui XU ,  Wei ZHANG ,  Juan SU ,  Chuan ZHANG

发明人： Cheng HE ,  Weidong ZHANG ,  Xiaohui XU ,  Wei ZHANG ,  Juan SU ,  Chuan ZHANG

IPC分类号： A61K31/35

CPC分类号： A61K31/37

摘要： A method for promoting differentiation of clonogenic neural stem cells (NSCs), comprising administering to a patient in the need of such promoting a coumarin compound represented by formula I or by formula II. The representative coumarin compounds include 7-hydroxycoumarin, daphnoretin, scopoletin, edgeworin, aesculetin and esculetin-6-β-D-glucopyranoside. The coumarin compounds showed significant activity of directing the differentiation of NSCs in pharmacological test and thereof could be used to prepare drugs to direct NSCs differentiated to oligodendrocyte progenitor cells (OPCs) for the treatment of demyelinating diseases or spinal cord injury. The drug could be a pure coumarin compound or a pharmaceutical composition comprising a therapeutical dose of a coumarin compound as active ingredients and a pharmaceutically-acceptable carrier. The content of the active ingredients in the pharmaceutical composition is between 0.1% and 99.5% by weight.

摘要翻译： 一种促进克隆型神经干细胞（NSCs）分化的方法，包括对需要这样促进由式I或式II表示的香豆素化合物的患者施用。 代表性的香豆素化合物包括7-羟基香豆素，芫花tin tin，scopoletin，edgeworin，七叶苷和七叶苷-6-β-D-吡喃葡萄糖苷。 香豆素化合物在药理学试验中显示出指导NSCs分化的显着活性，并且其可用于制备药物以指导分化为少突胶质细胞祖细胞（OPCs）的NSCs用于治疗脱髓鞘疾病或脊髓损伤。 药物可以是纯香豆素化合物或包含治疗剂量的香豆素化合物作为活性成分和药学上可接受的载体的药物组合物。 药物组合物中活性成分的含量为0.1〜99.5重量％。