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    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them
    2.
    发明授权
    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them 失效
    脱氢山梨醇，脱氢卡泊肽或其组合物的制备方法，其用途和含有它们的药物组合物

    公开(公告)号：US07732458B2

    公开(公告)日：2010-06-08

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4738 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

    METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM
    3.
    发明申请
    METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM 失效
    制备脱氢维生素，脱氢叶酸或其组合物的方法，其使用和含有它们的药物组合物

    公开(公告)号：US20100137350A9

    公开(公告)日：2010-06-03

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

    METHODS FOR DIRECTING DIFFERENTIATION OF CLONOGENIC NEURAL STEM CELLS WITH COUMARINS
    5.
    发明申请
    METHODS FOR DIRECTING DIFFERENTIATION OF CLONOGENIC NEURAL STEM CELLS WITH COUMARINS 审中-公开
    用COUMARIN指导克隆性神经干细胞分化的方法

    公开(公告)号：US20090170930A1

    公开(公告)日：2009-07-02

    申请号：US12400756

    申请日：2009-03-09

    申请人： Cheng HE ,  Weidong ZHANG ,  Xiaohui XU ,  Wei ZHANG ,  Juan SU ,  Chuan ZHANG

    发明人： Cheng HE ,  Weidong ZHANG ,  Xiaohui XU ,  Wei ZHANG ,  Juan SU ,  Chuan ZHANG

    IPC分类号： A61K31/35

    CPC分类号： A61K31/37

    摘要： A method for promoting differentiation of clonogenic neural stem cells (NSCs), comprising administering to a patient in the need of such promoting a coumarin compound represented by formula I or by formula II. The representative coumarin compounds include 7-hydroxycoumarin, daphnoretin, scopoletin, edgeworin, aesculetin and esculetin-6-β-D-glucopyranoside. The coumarin compounds showed significant activity of directing the differentiation of NSCs in pharmacological test and thereof could be used to prepare drugs to direct NSCs differentiated to oligodendrocyte progenitor cells (OPCs) for the treatment of demyelinating diseases or spinal cord injury. The drug could be a pure coumarin compound or a pharmaceutical composition comprising a therapeutical dose of a coumarin compound as active ingredients and a pharmaceutically-acceptable carrier. The content of the active ingredients in the pharmaceutical composition is between 0.1% and 99.5% by weight.

    摘要翻译： 一种促进克隆型神经干细胞（NSCs）分化的方法，包括对需要这样促进由式I或式II表示的香豆素化合物的患者施用。 代表性的香豆素化合物包括7-羟基香豆素，芫花tin tin，scopoletin，edgeworin，七叶苷和七叶苷-6-β-D-吡喃葡萄糖苷。 香豆素化合物在药理学试验中显示出指导NSCs分化的显着活性，并且其可用于制备药物以指导分化为少突胶质细胞祖细胞（OPCs）的NSCs用于治疗脱髓鞘疾病或脊髓损伤。 药物可以是纯香豆素化合物或包含治疗剂量的香豆素化合物作为活性成分和药学上可接受的载体的药物组合物。 药物组合物中活性成分的含量为0.1〜99.5重量％。

    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them
    7.
    发明申请
    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them 失效
    制备脱氢卡泊芬，脱氢卡泊肽或其组合物的方法，其用途和含有它们的医药组合物

    公开(公告)号：US20070249650A1

    公开(公告)日：2007-10-25

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。