公开(公告)号：US20140248348A1

公开(公告)日：2014-09-04

申请号：US14131050

申请日：2012-01-19

申请人： Chenggang Zhang ,  Junhuai Li ,  Yang Xu ,  Yonghong Wu ,  Weiguang Li ,  Yanchun Zhang ,  Yan Gao ,  Zhihui Li

发明人： Chenggang Zhang ,  Junhuai Li ,  Yang Xu ,  Yonghong Wu ,  Weiguang Li ,  Yanchun Zhang ,  Yan Gao ,  Zhihui Li

IPC分类号： A61K38/16 ,  A61K9/28

CPC分类号： C07K14/255 ,  A61K9/2806 ,  A61K9/2893 ,  A61K38/00 ,  A61K38/164 ,  C07K2319/00 ,  Y02A50/473 ,  Y02A50/481

摘要： The application of flagellin derivative CZLC31 from Salmonella in preparation of medicines for preventing and treating inflammatory bowel disease (IBD) is introduced in this invention. The CZLC331 protein has a good preventive and therapeutic effect for IBD, such as ulcerative colitis (UC) and Crohn's disease (CD) in this invention. Therefore, this protein can be prepared into the drug for prevention and treatment of IBD. It has been found that the bad efficacy, slow onset, long course of treatment, side effects can be significantly avoided for existing clinical IBD drugs, it can reduce the patient's pain during the treatment in this invention. The rehabilitation and quality of life of the patients have been largely improved. The drug will play an important role in the prevention and treatment of IBD in this invention, and has broad application prospects.

摘要翻译： 在本发明中引入了来自沙门氏菌的鞭毛蛋白衍生物CZLC31在制备用于预防和治疗炎症性肠病（IBD）的药物中的应用。 本发明中CZLC331蛋白质对IBD具有良好的预防和治疗作用，如溃疡性结肠炎（UC）和克罗恩氏病（CD）。 因此，该蛋白质可以制备成用于预防和治疗IBD的药物。 已经发现，对于现有的临床IBD药物，可以显着避免功效差，缓慢发作，长期治疗，副作用，可以减轻本发明治疗期间患者的疼痛。 患者的康复和生活质量已大大改善。 该药物在本发明预防和治疗IBD中起着重要作用，具有广泛的应用前景。

公开(公告)号：US09259453B2

公开(公告)日：2016-02-16

申请号：US14131050

申请日：2012-01-19

申请人： Chenggang Zhang ,  Junhuai Li ,  Yang Xu ,  Yonghong Wu ,  Weiguang Li ,  Yanchun Zhang ,  Yan Gao ,  Zhihui Li

发明人： Chenggang Zhang ,  Junhuai Li ,  Yang Xu ,  Yonghong Wu ,  Weiguang Li ,  Yanchun Zhang ,  Yan Gao ,  Zhihui Li

IPC分类号： C07K14/255 ,  A61K38/16 ,  A61K9/28

CPC分类号： C07K14/255 ,  A61K9/2806 ,  A61K9/2893 ,  A61K38/00 ,  A61K38/164 ,  C07K2319/00 ,  Y02A50/473 ,  Y02A50/481

摘要： The application of flagellin derivative CZLC31 from Salmonella in preparation of medicines for preventing and treating inflammatory bowel disease (IBD) is introduced in this invention. The CZLC331 protein has a good preventive and therapeutic effect for IBD, such as ulcerative colitis (UC) and Crohn's disease (CD) in this invention. Therefore, this protein can be prepared into the drug for prevention and treatment of IBD. It has been found that the bad efficacy, slow onset, long course of treatment, side effects can be significantly avoided for existing clinical IBD drugs, it can reduce the patient's pain during the treatment in this invention. The rehabilitation and quality of life of the patients have been largely improved. The drug will play an important role in the prevention and treatment of IBD in this invention, and has broad application prospects.

摘要翻译： 在本发明中引入了来自沙门氏菌的鞭毛蛋白衍生物CZLC31在制备用于预防和治疗炎症性肠病（IBD）的药物中的应用。 本发明中CZLC331蛋白质对IBD具有良好的预防和治疗作用，如溃疡性结肠炎（UC）和克罗恩氏病（CD）。 因此，该蛋白质可以制备成用于预防和治疗IBD的药物。 已经发现，对于现有的临床IBD药物，可以显着避免功效差，缓慢发作，长期治疗，副作用，可以减轻本发明治疗期间患者的疼痛。 患者的康复和生活质量已大大改善。 该药物在本发明预防和治疗IBD中起着重要作用，具有广泛的应用前景。

公开(公告)号：US09053021B2

公开(公告)日：2015-06-09

申请号：US13618815

申请日：2012-09-14

申请人： Zhihui Li ,  Kun He ,  Jun Yu ,  Yi Zhou

发明人： Zhihui Li ,  Kun He ,  Jun Yu ,  Yi Zhou

IPC分类号： G06F11/07 ,  G06F11/20

CPC分类号： G06F11/0709 ,  G06F11/1662 ,  G06F11/2069 ,  G06F11/2094 ,  G06F2201/815

摘要： Methods and systems for managing distributed storage servers are described. The storage servers may be selected and divided into multiple sequences and multiple virtual node groups. Each sequence of the multiple sequences may include a predetermined number of storage servers, and each virtual node group may include a set of storage servers of the multiple sequences. Data may be transferred to storage severs of a virtual node group. If the storage servers have instantaneous or temporary malfunctions, the data may be transferred to temporary storage servers and then transferred back the storage servers after being revived. If the storage servers have permanent malfunctions, the data may be transferred to the temporary storage servers. The storage servers may be replaced using the temporary storage servers.

摘要翻译： 描述用于管理分布式存储服务器的方法和系统。 可以选择存储服务器并将其划分为多个序列和多个虚拟节点组。 多个序列的每个序列可以包括预定数量的存储服务器，并且每个虚拟节点组可以包括多个序列的一组存储服务器。 数据可以传送到虚拟节点组的存储切换器。 如果存储服务器具有即时或暂时的故障，则数据可能会传输到临时存储服务器，然后在恢复后将存储服务器传回。 如果存储服务器具有永久性故障，则数据可能会传输到临时存储服务器。 可以使用临时存储服务器来替换存储服务器。

公开(公告)号：US09993865B2

公开(公告)日：2018-06-12

申请号：US13138129

申请日：2010-06-25

申请人： Baiqing Xiong ,  Yongan Zhang ,  Baohong Zhu ,  Xiwu Li ,  Zhihui Li ,  Feng Wang ,  Hongwei Liu

发明人： Baiqing Xiong ,  Yongan Zhang ,  Baohong Zhu ,  Xiwu Li ,  Zhihui Li ,  Feng Wang ,  Hongwei Liu

IPC分类号： C22C21/10 ,  C22F1/053 ,  B22D7/00 ,  B22D18/04 ,  B22D27/02 ,  B22D27/08

CPC分类号： B22D7/005 ,  B22D18/04 ,  B22D27/02 ,  B22D27/08 ,  C22C21/10 ,  C22F1/053

摘要： An aluminum alloy product for manufacturing structural components, made from direct chill casting ingots comprises, based on wt %: Zn 7.5˜8.7, Mg 1.1˜2.3, Cu 0.5˜1.9, Zr 0.03˜0.20, the balance being Al, incidental elements and impurities. The levels of Zn, Mg, Cu, and Zr in the aluminum alloy products satisfy the expressions of (a) 10.5≤Zn+Mg+Cu≤11.0; (b) 5.3≤(Zn/Mg)+Cu≤6.0; and (c) (0.24−D/4800)≤Zr≤(0.24−D/5000). D is the minimum length of a line section connecting any two points on the periphery of the cross section of the ingot and passing through the geometrical center of the cross section. 250 mm≤D≤1000 mm. The aluminum alloy products have a superior combination of strength and damage tolerance, and exhibit homogeneous and consistent performance on the surface, at various depths under the surface, and in the core of the product. A method of producing the aluminum alloy products is also provided.

公开(公告)号：US20110297278A1

公开(公告)日：2011-12-08

申请号：US13138129

申请日：2010-06-25

申请人： Baiqing Xiong ,  Yongan Zhang ,  Baohong Zhu ,  Xiwu Li ,  Zhihui Li ,  Feng Wang ,  Hongwei Liu

发明人： Baiqing Xiong ,  Yongan Zhang ,  Baohong Zhu ,  Xiwu Li ,  Zhihui Li ,  Feng Wang ,  Hongwei Liu

IPC分类号： C22F1/053 ,  C22C21/10

CPC分类号： B22D7/005 ,  B22D18/04 ,  B22D27/02 ,  B22D27/08 ,  C22C21/10 ,  C22F1/053

摘要： An aluminium alloy product for manufacturing structural components, made from direct chill casting ingots comprises, based on wt %: Zn 7.5˜8.7, Mg 1.1˜2.3, Cu 0.5˜1.9, Zr 0.03˜0.20, the balance being Al, incidental elements and impurities. The levels of Zn, Mg, Cu, and Zr in the aluminum alloy products satisfy the expressions of (a) 10.5≦Zn+Mg+Cu≦11.0; (b) 5.3≦(Zn/Mg)+Cu≦6.0; and (c) (0.24−D/4800)≦Zr≦(0.24−D/5000). D is the minimum length of a line section connecting any two points on the periphery of the cross section of the ingot and passing through the geometrical center of the cross section. 250 mm≦D≦1000 mm. The aluminum alloy products have a superior combination of strength and damage tolerance, and exhibit homogeneous and consistent performance on the surface, at various depths under the surface, and in the core of the product. A method of producing the aluminum alloy products is also provided.

摘要翻译： 用于制造直接冷却铸锭的结构部件的铝合金产品包括：基于wt％：Zn 7.5〜7.8，Mg 1.1〜2.3，Cu 0.5〜1.9，Zr 0.03〜0.20，余量为Al，附带元素和 杂质。 铝合金产品中的Zn，Mg，Cu和Zr的含量满足（a）10.5＆nlE; Zn + Mg + Cu＆NlE; 11.0; （b）5.3＆nlE;（Zn / Mg）+ Cu＆nlE; 6.0; 和（c）（0.24-D / 4800）＆nlE; Zr＆nlE;（0.24-D / 5000）。 D是连接锭的横截面的周边上的两个点并穿过横截面的几何中心的线段的最小长度。 250 mm＆nlE; D＆nlE; 1000 mm。 铝合金产品具有优异的强度和耐受性的组合，并且在表面上，在表面下的不同深度以及产品的核心中表现出均匀且一致的性能。 还提供了一种生产铝合金产品的方法。