公开(公告)号：US10336682B1

公开(公告)日：2019-07-02

申请号：US16359982

申请日：2019-03-20

申请人： Chengyuan Liang ,  Lei Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao ,  Gennian Mao ,  Nan Qin ,  Juan Xia ,  Zhenfeng Shi

发明人： Chengyuan Liang ,  Lei Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao ,  Gennian Mao ,  Nan Qin ,  Juan Xia ,  Zhenfeng Shi

IPC分类号： C07C69/757 ,  B01J31/02 ,  C07C67/08

摘要： A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10343988B1

公开(公告)日：2019-07-09

申请号：US16359988

申请日：2019-03-20

申请人： Chengyuan Liang ,  Lei Tian ,  Danni Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao

发明人： Chengyuan Liang ,  Lei Tian ,  Danni Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao

IPC分类号： C07C323/56 ,  C07C319/20 ,  C09K15/14

摘要： A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10766885B1

公开(公告)日：2020-09-08

申请号：US16871333

申请日：2020-05-11

申请人： Xingke Ju ,  Chengyuan Liang ,  Bin Tian ,  Yuzhi Liu ,  Lei Tian ,  Gennian Mao ,  Limei Wang ,  Yuanyuan He ,  Yongbo Wang ,  Jingwen Xu ,  Dan Yang ,  Liang Qi ,  Wenbo Yao ,  Qianqian Zhao ,  Han Li

发明人： Xingke Ju ,  Chengyuan Liang ,  Bin Tian ,  Yuzhi Liu ,  Lei Tian ,  Gennian Mao ,  Limei Wang ,  Yuanyuan He ,  Yongbo Wang ,  Jingwen Xu ,  Dan Yang ,  Liang Qi ,  Wenbo Yao ,  Qianqian Zhao ,  Han Li

IPC分类号： C07D407/14 ,  B01J31/02

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US11306076B2

公开(公告)日：2022-04-19

申请号：US16871354

申请日：2020-05-11

申请人： Yonghong Tang ,  Huafeng Qi ,  Peiyu Zhou ,  Xingke Ju ,  Chengyuan Liang ,  Yuzhi Liu ,  Bin Tian ,  Lei Tian ,  Gennian Mao ,  Limei Wang ,  Yuanyuan He ,  Yongbo Wang ,  Jingwen Xu ,  Dan Yang ,  Liang Qi ,  Wenbo Yao ,  Qianqian Zhao ,  Han Li

发明人： Yonghong Tang ,  Huafeng Qi ,  Peiyu Zhou ,  Xingke Ju ,  Chengyuan Liang ,  Yuzhi Liu ,  Bin Tian ,  Lei Tian ,  Gennian Mao ,  Limei Wang ,  Yuanyuan He ,  Yongbo Wang ,  Jingwen Xu ,  Dan Yang ,  Liang Qi ,  Wenbo Yao ,  Qianqian Zhao ,  Han Li

IPC分类号： C07D409/14 ,  B01J27/24

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US10662201B2

公开(公告)日：2020-05-26

申请号：US16167590

申请日：2018-10-23

申请人： Chengyuan Liang ,  Xingke Ju ,  Lei Tian ,  Nan Qin ,  Juan Xia ,  Shaomeng Pei ,  Han Li ,  Yuzhi Liu

发明人： Chengyuan Liang ,  Xingke Ju ,  Lei Tian ,  Nan Qin ,  Juan Xia ,  Shaomeng Pei ,  Han Li ,  Yuzhi Liu

IPC分类号： C07D498/10 ,  A61P11/06 ,  A61P29/00

摘要： A compound of chemical formula I: or chemical formula II: or a pharmaceutical acceptable salt thereof is disclosed. R1, R2, R3, and R4 are independently H, halogen, nitro, hydroxyl, cyano, benzyloxy, C1-C8 straight or branched alkyl, C1-C8 straight or branched haloalkyl, C1-C8 straight or branched alkoxy.

公开(公告)号：US10377702B1

公开(公告)日：2019-08-13

申请号：US16426560

申请日：2019-05-30

申请人： Chengyuan Liang ,  Yuzhi Liu ,  Xingke Ju ,  Yonghong Tang ,  Gennian Mao ,  Qianqian Zhao ,  Bin Tian ,  Jian Zha ,  Chunyang Shi ,  Yongbo Wang ,  Huayin Pu ,  Yanghan Liu

发明人： Chengyuan Liang ,  Yuzhi Liu ,  Xingke Ju ,  Yonghong Tang ,  Gennian Mao ,  Qianqian Zhao ,  Bin Tian ,  Jian Zha ,  Chunyang Shi ,  Yongbo Wang ,  Huayin Pu ,  Yanghan Liu

IPC分类号： C07C269/02 ,  B01J31/02 ,  B01D15/16

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US10995053B1

公开(公告)日：2021-05-04

申请号：US16826045

申请日：2020-03-20

申请人： Han Li ,  Nan Hui ,  Bin Tian ,  Xingke Ju ,  Yuzhi Liu ,  Dan Yang ,  Jingwen Xu ,  Liang Qi ,  Qianqian Zhao ,  Yongbo Wang

发明人： Han Li ,  Nan Hui ,  Bin Tian ,  Xingke Ju ,  Yuzhi Liu ,  Dan Yang ,  Jingwen Xu ,  Liang Qi ,  Qianqian Zhao ,  Yongbo Wang

IPC分类号： C07C67/08 ,  B01J20/291 ,  B01J31/02

摘要： A compound having the formula (I): is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.

公开(公告)号：US10472321B1

公开(公告)日：2019-11-12

申请号：US16510907

申请日：2019-07-13

申请人： Chengyuan Liang ,  Yuzhi Liu ,  Xingke Ju ,  Yonghong Tang ,  Minghui Chang ,  Bin Tian ,  Dan Yang ,  Han Li ,  Ning Liu ,  Huayin Pu ,  Jian Cha ,  Juanna Song ,  Yongbo Wang

发明人： Chengyuan Liang ,  Yuzhi Liu ,  Xingke Ju ,  Yonghong Tang ,  Minghui Chang ,  Bin Tian ,  Dan Yang ,  Han Li ,  Ning Liu ,  Huayin Pu ,  Jian Cha ,  Juanna Song ,  Yongbo Wang

IPC分类号： C07C271/26 ,  B01J31/02 ,  C07C269/02

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US10233183B1

公开(公告)日：2019-03-19

申请号：US16043085

申请日：2018-07-23

申请人： Chengyuan Liang ,  Lei Tian ,  Yonghong Tang ,  Minghui Chang ,  Kaiqi Shi ,  Xingke Ju ,  Yuzhi Liu ,  Lili Wen ,  Han Li ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Lei Tian ,  Yonghong Tang ,  Minghui Chang ,  Kaiqi Shi ,  Xingke Ju ,  Yuzhi Liu ,  Lili Wen ,  Han Li ,  Xuechuan Wang

IPC分类号： C07D471/22

摘要： A compound having the following formula I: In formula I, R1 and R2 are independently H, alkyl, alkoxy, and halogen. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

发明人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.