公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Shunjun Ding ,  Chengyuan Liang

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Zhong Meng ,  Jianguo Meng ,  Yu Wang ,  Shunjun Ding ,  Chengyuan Liang ,  Liang Xin ,  Jingyi Li ,  Jiayun Zhang ,  Kangxiong Wu ,  Juan Xia ,  Han Li

IPC分类号： C07C271/02 ,  C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

公开(公告)号：US10072020B1

公开(公告)日：2018-09-11

申请号：US15957867

申请日：2018-04-19

申请人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D491/107

CPC分类号： C07D491/107

摘要： An isatin spiro compound having the following formula (I): R1 is halogen or C1-3 alkyl; R2 is C1-3 alkyl or benzyl; and R3 and R3′ are independently H, C1-3 alkyl or phenyl.

公开(公告)号：US10023765B2

公开(公告)日：2018-07-17

申请号：US15605985

申请日：2017-05-26

申请人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

发明人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

IPC分类号： C09H3/02 ,  B05D3/00 ,  B05D1/18 ,  B65D65/46

摘要： A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.

公开(公告)号：US10336689B1

公开(公告)日：2019-07-02

申请号：US16359963

申请日：2019-03-20

申请人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

发明人： Chengyuan Liang ,  Shunjun Ding ,  Nan Hui ,  Juan Li ,  Dezhu Zhang ,  Xiaolin Xie

IPC分类号： C07C251/24 ,  A61P35/00 ,  C07C249/02

摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US20180094167A1

公开(公告)日：2018-04-05

申请号：US15605985

申请日：2017-05-26

申请人： Chengyuan LIANG ,  Danni TIAN ,  Minyi JIA ,  Shunjun DING ,  Xuechuan WANG ,  Han LI ,  Wei LIU

发明人： Chengyuan LIANG ,  Danni TIAN ,  Minyi JIA ,  Shunjun DING ,  Xuechuan WANG ,  Han LI ,  Wei LIU

IPC分类号： C09H3/02 ,  B05D3/00 ,  B05D1/18 ,  B65D65/46

CPC分类号： C09H3/02 ,  B05D1/18 ,  B05D3/007 ,  B65D65/463

摘要： A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.

公开(公告)号：US20230128907A1

公开(公告)日：2023-04-27

申请号：US17942941

申请日：2022-09-12

申请人： Jia WAN ,  Chunchun KONG ,  Shunjun DING ,  Jingyi LI ,  Lei TIAN

发明人： Jia WAN ,  Chunchun KONG ,  Shunjun DING ,  Jingyi LI ,  Lei TIAN

IPC分类号： A61K36/896 ,  A61K31/7048 ,  A61P31/04

摘要： A method of preparing a Paris polyphylla saponin extract includes: (1) adding Paris polyphylla saponin in 60-90% ethanol to obtain a mixture, heating the mixture under reflux for 2-4 hours; (2) concentrating the mixture to ¼ volume, centrifuging the mixture to obtain a supernatant A and a precipitate A, adding the precipitate A to 60-80% ethanol to obtain a supernatant B and a precipitate B, washing the precipitate B with water and petroleum ether and drying; and (3) combining the supernatant A and the supernatant B, mixing with a macroporous adsorption resin, loading to a chromatography column, eluting the chromatography column with water and 80-90% ethanol, collecting an ethanol eluent, concentrating the ethanol eluent to obtain an eluent extract, and combining the eluent extract and the precipitate B and drying to obtain the Paris polyphylla saponin extract.

公开(公告)号：US20200147057A1

公开(公告)日：2020-05-14

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin XIE ,  Dezhu ZHANG ,  Shunjun DING ,  Chengyuan LIANG

发明人： Xiaolin XIE ,  Dezhu ZHANG ,  Shunjun DING ,  Chengyuan LIANG

IPC分类号： A61K31/437 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10100036B2

公开(公告)日：2018-10-16

申请号：US15713934

申请日：2017-09-25

申请人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D401/12

摘要： A lappaconitine aza-cinnamic acid derivative having the following formula (I): X is C or N, and R1, R2, and R3 are independently H or lower alkyl. A method of preparing the lappaconitine aza-cinnamic acid derivative of formula (I) is also disclosed.