公开(公告)号：US08952165B2

公开(公告)日：2015-02-10

申请号：US13980821

申请日：2012-01-30

申请人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Eun Jung Yi

发明人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Eun Jung Yi

IPC分类号： C07D453/02 ,  C07D417/14 ,  C07D471/08 ,  A61K31/4748

CPC分类号： A61K31/439 ,  A61K9/0053 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  C07D453/02

摘要： A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical composition for cognitive disorders that includes the pyridone derivative compound or a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof.

摘要翻译： 吡啶酮衍生物化合物及其药学上可接受的盐，异构体，溶剂合物或水合物，以及包括吡啶酮衍生化合物或其药学上可接受的盐，异构体，溶剂化物或水合物的认知障碍的预防或治疗药物组合物。

公开(公告)号：US08716309B2

公开(公告)日：2014-05-06

申请号：US13980819

申请日：2012-01-30

申请人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Hwa Ryun Cha ,  Eun Jung Yi

发明人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Hwa Ryun Cha ,  Eun Jung Yi

IPC分类号： A01N43/90 ,  A61K31/44 ,  C07D453/02

CPC分类号： C07D453/02

摘要： A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical composition for cognitive disorders that includes the pyridone derivative compound or a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof.

摘要翻译： 吡啶酮衍生物化合物及其药学上可接受的盐，异构体，溶剂合物或水合物，以及包括吡啶酮衍生化合物或其药学上可接受的盐，异构体，溶剂化物或水合物的认知障碍的预防或治疗药物组合物。

公开(公告)号：US20130317059A1

公开(公告)日：2013-11-28

申请号：US13980819

申请日：2012-01-30

申请人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Hwa Ryun Cha ,  Eun Jung Yi

发明人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Hwa Ryun Cha ,  Eun Jung Yi

IPC分类号： C07D453/02

CPC分类号： C07D453/02

摘要： A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical composition for cognitive disorders that includes the pyridone derivative compound or a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof.

公开(公告)号：US20130296340A1

公开(公告)日：2013-11-07

申请号：US13980821

申请日：2012-01-30

申请人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Eun Jung Yi

发明人： Cheol Young Maeng ,  Young Koo Jang ,  Su Bong Cha ,  Hye Won Shin ,  Chan Mi Joung ,  Eun Jung Yi

IPC分类号： C07D453/02

CPC分类号： A61K31/439 ,  A61K9/0053 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  C07D453/02

摘要： A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical composition for cognitive disorders that includes the pyridone derivative compound or a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof.

公开(公告)号：US08507553B2

公开(公告)日：2013-08-13

申请号：US13489270

申请日：2012-06-05

申请人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

发明人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

IPC分类号： A61K31/34 ,  C07D307/00

CPC分类号： C07D307/80 ,  C07D307/82 ,  C07D307/83

摘要： The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

摘要翻译： 本发明涉及新型苯并呋喃衍生物及其制备方法及其组合物。 本发明的苯并呋喃衍生物显示出β-淀粉样蛋白聚集和细胞毒性的有效抑制活性，从而刺激神经元细胞的增殖，以及使用具有β-淀粉样蛋白前体的转化动物模型恢复由神经细胞损伤引起的记忆学习损伤的活性 因此该化合物可用于治疗或预防认知功能障碍。

公开(公告)号：US08580848B2

公开(公告)日：2013-11-12

申请号：US13489261

申请日：2012-06-05

申请人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

发明人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

IPC分类号： A61K31/34 ,  C07D307/00

CPC分类号： C07D307/80 ,  C07D307/82 ,  C07D307/83

摘要： The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

公开(公告)号：US08455542B2

公开(公告)日：2013-06-04

申请号：US13489263

申请日：2012-06-05

申请人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

发明人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

IPC分类号： A61K31/34 ,  C07D307/00

CPC分类号： C07D307/80 ,  C07D307/82 ,  C07D307/83

摘要： The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

公开(公告)号：US08263649B2

公开(公告)日：2012-09-11

申请号：US12443972

申请日：2007-10-02

申请人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

发明人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

IPC分类号： A61K31/34 ,  C07D307/00

CPC分类号： C07D307/80 ,  C07D307/82 ,  C07D307/83

摘要： The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

摘要翻译： 本发明涉及新型苯并呋喃衍生物及其制备方法及其组合物。 本发明的苯并呋喃衍生物显示出β-淀粉样蛋白聚集和细胞毒性的有效抑制活性，从而刺激神经元细胞的增殖，以及使用具有β-淀粉样蛋白前体的转化动物模型恢复由神经细胞损伤引起的记忆学习损伤的活性 因此该化合物可用于治疗或预防认知功能障碍。

公开(公告)号：US20100197685A1

公开(公告)日：2010-08-05

申请号：US12443972

申请日：2007-10-02

申请人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

发明人： Dong Wook Kang ,  Jee Woo Lee ,  Young Ho Kim ,  Hee Kim ,  Hee Jin Ha ,  Eun Joo Nam ,  Chan Mi Joung

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4525 ,  A61K31/343 ,  C07D413/04 ,  C07D405/04 ,  C07D401/04 ,  C07D307/80 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D307/80 ,  C07D307/82 ,  C07D307/83

摘要： The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.

摘要翻译： 本发明涉及新型苯并呋喃衍生物及其制备方法及其组合物。 本发明的苯并呋喃衍生物显示出β-淀粉样蛋白聚集和细胞毒性的有效抑制活性，从而刺激神经元细胞的增殖，以及使用具有β-淀粉样蛋白前体的转化动物模型恢复由神经元细胞损伤引起的记忆学习损伤的活性 因此该化合物可用于治疗或预防认知功能障碍。