公开(公告)号：US20190134263A1

公开(公告)日：2019-05-09

申请号：US14003062

申请日：2012-03-01

申请人： Cheul H Cho ,  Ali Hussain ,  George Collins ,  Divya Ranendran

发明人： Cheul H Cho ,  Ali Hussain ,  George Collins ,  Divya Ranendran

IPC分类号： A61L27/26

摘要： The present invention relates to a vascularized three dimensional construct for thick tissue, a process for making the construct and to the use of the construct in tissue regeneration and repair and in drug development. The three-dimensional (3-D) tissue technology is used to generate vascularized, biomimetic tissue models in vitro utilizing a biodegradable nanofiber scaffold. The culture system allows the maintenance of long-term survival and function of liver and heart cells. The system utilizes a novel approach to generate structures that mimic in vivo tissue architecture. The system provides a microenvironment for forming 3-D microvascular networks within the nanofiber scaffolds.