公开(公告)号：US20120278000A1

公开(公告)日：2012-11-01

申请号：US13457081

申请日：2012-04-26

申请人： Chihiro SUMINAKA ,  Amame HARADA ,  Tomoko OHYAMA ,  Yasuhiro TORIKOSHI

发明人： Chihiro SUMINAKA ,  Amame HARADA ,  Tomoko OHYAMA ,  Yasuhiro TORIKOSHI

IPC分类号： G06F19/00

CPC分类号： C12Q1/485 ,  G01N33/573 ,  G01N33/57415 ,  G01N2333/91177 ,  G01N2800/52 ,  G16B20/00

摘要： A method for assessing an efficacy of combination chemotherapy, comprising: a first obtaining process for obtaining a specific activity value of Cyclin Dependent Kinase (CDK) 1 and a specific activity value of CDK2 in a biological sample including a carcinoma cell collected from a cancer patient; a second obtaining process for obtaining a GSTπ expression level in the biological sample; and an assessment process for assessing the efficacy of the combination chemotherapy on the cancer patient based on the specific activity values of CDK1 and CDK2 obtained in the first obtaining process and the GSTπ expression level obtained in the second obtaining process.

摘要翻译： 一种评估联合化疗疗效的方法，包括：获得细胞周期蛋白依赖性激酶（CDK）1的比活性值的第一获得方法和包含从癌症患者收集的癌细胞的生物样品中CDK2的比活性值 ; 获得GST＆pgr的第二获取过程 生物样品中的表达水平; 以及基于在第一获得方法和GST＆pgr中获得的CDK1和CDK2的比活性值来评估联合化疗对癌症患者的功效的评估过程。 在第二获得过程中获得的表达水平。