公开(公告)号：US07115865B2

公开(公告)日：2006-10-03

申请号：US10908953

申请日：2005-06-01

Applicant: Ching-Pin Chang ,  Ching-Ching Shih ,  Ting-Wei Chen

Inventor： Ching-Pin Chang ,  Ching-Ching Shih ,  Ting-Wei Chen

IPC: H01J37/256

CPC classification number: G01N1/36 ,  G01N2001/364

Abstract: The present invention discloses a method of applying micro-protection in defect analysis. The method includes providing a substrate having at least one defect thereon, forming the micro-protection on the surface of the defect, confirming the site of the defect, and forming a specimen of the defect by utilizing a focused ion beam microscope.

Abstract translation: 本发明公开了一种在缺陷分析中应用微保护的方法。 该方法包括提供其上具有至少一个缺陷的基板，在缺陷表面上形成微保护，确认缺陷部位，并通过利用聚焦离子束显微镜形成缺陷样本。

公开(公告)号：US20130109738A1

公开(公告)日：2013-05-02

申请号：US13580122

申请日：2011-02-23

Applicant: Ching-Pin Chang ,  Calvin Hang ,  Pei Han ,  Jin Yang ,  Ksiu-Ling Cheng

Inventor： Ching-Pin Chang ,  Calvin Hang ,  Pei Han ,  Jin Yang ,  Ksiu-Ling Cheng

IPC: A61K31/7088 ,  A61K31/138 ,  G01N33/68

CPC classification number: A61K31/7088 ,  A61K31/00 ,  A61K31/138 ,  G01N33/6887

Abstract: Methods and compositions are provided for the diagnosis and treatment of heart diseases relating to cardiac hypertrophy, and for the regulation of proliferation and differentiation of cardiomyocyte progenitors in vitro. The detection of expression of components of the BAF complex, including, without limitation, detection of expression of Brg1, provides useful methods for early detection, diagnosis, staging, and monitoring of conditions leading to hypertrophy and enlargement of the heart. Manipulation of Brg1 activity provides for therapeutic intervention in the development of cardiac hypertrophy, where methods of decreasing Brg1 activity, e.g. through inhibition of binding, decreasing expression, and the like, reduces cardiac hypertrophy.

Abstract translation: 提供了用于诊断和治疗与心脏肥大相关的心脏疾病的方法和组合物，以及用于体外调节心肌细胞祖细胞增殖和分化的方法和组合物。 检测BAF复合物组分的表达，包括但不限于检测Brg1的表达，为早期检测，诊断，分期和监测导致心脏肥大和扩大的病症提供了有用的方法。 Brg1活性的操作提供治疗干预心脏肥大的发展，其中减少Brg1活性的方法，例如， 通过抑制结合，降低表达等减少心脏肥大。