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公开(公告)号:US20060154955A1
公开(公告)日:2006-07-13
申请号:US11330540
申请日:2006-01-12
申请人: Chongqing Sun , William Ewing , Yanting Huang
发明人: Chongqing Sun , William Ewing , Yanting Huang
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, n, Y and Z are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 化合物具有通式I:包括所有药学上可接受的盐和立体异构体,R 1,R 2,R 3,R 3, 3a,R 4,n,Y和Z在本文中描述。
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公开(公告)号:US20100048612A1
公开(公告)日:2010-02-25
申请号:US12609436
申请日:2009-10-30
申请人: Chongqing Sun , Yanting Huang , Doree F. Sitkoff , Taekyu Lee , William Ewing
发明人: Chongqing Sun , Yanting Huang , Doree F. Sitkoff , Taekyu Lee , William Ewing
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04 , C07D487/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein A, B, R1, R2, R3 and R8 are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 该化合物具有以下通式:包括所有前药,溶剂化物,药学上可接受的盐和立体异构体,其中A,B,R 1,R 2,R 3和R 8在本文中描述。
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公开(公告)号:US20060287324A1
公开(公告)日:2006-12-21
申请号:US11455039
申请日:2006-06-16
申请人: Chongqing Sun , Yanting Huang , Doree Sitkoff , Taekyu Lee , William Ewing
发明人: Chongqing Sun , Yanting Huang , Doree Sitkoff , Taekyu Lee , William Ewing
IPC分类号: A61K31/503 , A61K31/4745 , C07D487/04 , C07D471/02
CPC分类号: C07D471/04 , C07D487/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein A, B, R1, R2, R3 and R8 are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 所述化合物具有以下通式:包括所有前药,溶剂化物,药学上可接受的盐和立体异构体,其中A,B,R 1,R 2,R 3 本文描述了本文和/或 SUP> 8。
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公开(公告)号:US20060155126A1
公开(公告)日:2006-07-13
申请号:US11330541
申请日:2006-01-12
申请人: Chongqing Sun , William Ewing , Richard Sulsky , Yanting Huang
发明人: Chongqing Sun , William Ewing , Richard Sulsky , Yanting Huang
IPC分类号: C07D471/02 , C07D487/02
CPC分类号: C07D471/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, n, Y and Z are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I:包括所有前药,药学上可接受的盐和立体异构体,R 1,R 2,R 3,R 3, 本文描述了SUP,3a,R 4,A,B,n,Y和Z。
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公开(公告)号:US20070004772A1
公开(公告)日:2007-01-04
申请号:US11454322
申请日:2006-06-16
申请人: Chongqing Sun , Philip Sher , Gang Wu , William Ewing , Yanting Huang , Taekyu Lee , Natesan Murugesan , Richard Sulsky
发明人: Chongqing Sun , Philip Sher , Gang Wu , William Ewing , Yanting Huang , Taekyu Lee , Natesan Murugesan , Richard Sulsky
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R1, R2, R3, R4 and R5 are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物,以及使用式I化合物单独和与一种或多种 其他治疗剂。 该化合物具有以下通式:包括所有前药,溶剂化物,药学上可接受的盐和立体异构体,其中R 1,R 2,R 3, 本文描述了R 4和R 5。
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公开(公告)号:US20060287322A1
公开(公告)日:2006-12-21
申请号:US11455045
申请日:2006-06-16
申请人: Chongqing Sun , Yanting Huang , Doree Sitkoff , Guixue Yu , Amarendra Mikkilineni , William Ewing
发明人: Chongqing Sun , Yanting Huang , Doree Sitkoff , Guixue Yu , Amarendra Mikkilineni , William Ewing
IPC分类号: A61K31/503 , C07D487/02 , A61K31/53
CPC分类号: C07D487/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formulas I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formulas: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein B, R1, R2, R3 and x are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物单独治疗并与一种或多种另外的组合的治疗方法 治疗剂。 该化合物具有以下通式:包括所有前药,溶剂化物,药学上可接受的盐和立体异构体,其中B,R 1,R 2,R 3, SUP>和x。
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公开(公告)号:US20060160850A1
公开(公告)日:2006-07-20
申请号:US11334204
申请日:2006-01-18
申请人: Chongqing Sun , William Ewing , Yanting Huang , Annapurna Pendri , Samuel Gerritz , Bruce Ellsworth , Natesan Murugesan
发明人: Chongqing Sun , William Ewing , Yanting Huang , Annapurna Pendri , Samuel Gerritz , Bruce Ellsworth , Natesan Murugesan
IPC分类号: A61K31/47 , C07D215/38 , A61K31/4709
CPC分类号: C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/06
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, n, and Z are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 化合物具有通式I:包括所有前药,药学上可接受的盐和立体异构体,R 1,R 2,R 3,N, 和Z。
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公开(公告)号:US20060154956A1
公开(公告)日:2006-07-13
申请号:US11330656
申请日:2006-01-12
申请人: Chongqing Sun , William Ewing , Yanting Huang , Yeheng Zhu
发明人: Chongqing Sun , William Ewing , Yanting Huang , Yeheng Zhu
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04 , C07D487/04 , C07D513/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R3a, R4, A, B, b, n, W, X, Y and Z are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I:包括所有前药,药学上可接受的盐和立体异构体,R 1,R 2,R 3,R 3, 本文描述了SUP,3a,R 4,A,B,b,n,W,X,Y和Z。
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公开(公告)号:US07632837B2
公开(公告)日:2009-12-15
申请号:US11455039
申请日:2006-06-16
申请人: Chongqing Sun , Yanting Huang , Doree F. Sitkoff , Taekyu Lee , William Ewing
发明人: Chongqing Sun , Yanting Huang , Doree F. Sitkoff , Taekyu Lee , William Ewing
IPC分类号: C07D487/04 , A61K31/5025
CPC分类号: C07D471/04 , C07D487/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein A, B, R1, R2, R3 and R8 are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 该化合物具有以下通式:包括所有前药,溶剂化物,药学上可接受的盐和立体异构体,其中A,B,R 1,R 2,R 3和R 8在本文中描述。
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公开(公告)号:US20050143381A1
公开(公告)日:2005-06-30
申请号:US11016135
申请日:2004-12-17
申请人: Guixue Yu , William Ewing , Amarendra Mikkilineni , Annapurna Pendri , Philip Sher , Samuel Gerritz , Bruce Ellsworth , Gang Wu , Yanting Huang , Chongqing Sun , Natesan Murugesan , Zhengxiang Gu , Ying Wang , Doree Sitkoff , Stephen Johnson , Ximao Wu
发明人: Guixue Yu , William Ewing , Amarendra Mikkilineni , Annapurna Pendri , Philip Sher , Samuel Gerritz , Bruce Ellsworth , Gang Wu , Yanting Huang , Chongqing Sun , Natesan Murugesan , Zhengxiang Gu , Ying Wang , Doree Sitkoff , Stephen Johnson , Ximao Wu
IPC分类号: A61K31/5025 , C07D487/04 , A61K31/503
CPC分类号: C07D487/04
摘要: The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.
摘要翻译: 本申请描述了根据式I的化合物,包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法,其单独和与一种或多种另外的 治疗剂。 该化合物具有通式I:包括所有前药,药学上可接受的盐和立体异构体,R 1,R 2,R 3,R 3, 本文描述了SUP 6,R 7,m和n。
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