公开(公告)号：US20210220416A1

公开(公告)日：2021-07-22

申请号：US17257429

申请日：2019-07-03

Applicant: Chr. Hansen A/S

Inventor： Mogens DOLMER ,  Mette INGEMANN ,  Mette WINNING

IPC: A61K35/747 ,  A61K35/745 ,  A61K47/06 ,  A61K9/00 ,  A61K9/16 ,  A61K45/06 ,  A61K47/44 ,  A61K47/14

Abstract: The present invention relates to topical compositions comprising at least 106 CFU/g probiotic bacteria that remain viable in said composition for at least 6 months at 25° C./60% RH. The present invention also relates to methods for preparing such topical compositions, and a device suitable for long-term storage of viable probiotic bacteria. In addition, the present invention relates to the use of said composition.

公开(公告)号：US20210275613A1

公开(公告)日：2021-09-09

申请号：US17257422

申请日：2019-07-03

Applicant: Chr. Hansen A/S

Inventor： Mogens DOLMER ,  Mette INGEMANN ,  Mette WINNING

IPC: A61K35/747 ,  A61K9/00 ,  A61K35/745 ,  A61K9/06 ,  B65D81/26

Abstract: The present invention relates to aqueous topical compositions comprising at least 1·106 CFU/g probiotic bacteria that remain viable in said composition for at least 14 days at 25° C./60% RH or 30° C./75% RH or 5° C. The present invention also relates to methods for preparing such aqueous topical compositions, and a device suitable for long-term storage of viable bacteria of at least one probiotic bacterial strain and a water miscible solvent. In addition, the present invention relates to the use of said delivery device for providing probiotic bacteria that remain viable in said aqueous topical composition. Once the user needs the aqueous topical composition of the invention, the compartments in the device are mixed and a stable ready-to-use aqueous topical composition of the invention is provided with at least 1·106 CFU/g viable bacteria of at least one probiotic bacterial strain for up to 14 days at 25° C./60% RH or 30° C./75% RH or 5° C.