公开(公告)号：US12128076B2

公开(公告)日：2024-10-29

申请号：US16959016

申请日：2019-01-14

申请人： GI INNOVATION, INC.

发明人： Myoung Ho Jang ,  Young Chul Sung ,  Zungyoon Yang

IPC分类号： A61K35/745 ,  A61K9/00 ,  A61K9/14 ,  A61K9/19 ,  A61K35/744 ,  A61K35/747 ,  A61K38/17 ,  A61K39/395 ,  A61P37/08 ,  C07K14/735 ,  C07K16/42

CPC分类号： A61K35/745 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/14 ,  A61K9/19 ,  A61K35/744 ,  A61K35/747 ,  A61K38/1774 ,  A61K39/39566 ,  A61P37/08 ,  C07K14/70535 ,  C07K16/4291 ,  C07K2317/52 ,  C07K2317/60 ,  C07K2317/92 ,  C07K2319/30

摘要： A composition containing, as active ingredients, probiotics and a polypeptide with a binding ability to IgE is disclosed. In particular, a synergistic effect of remarkably decreasing food allergy was identified at the time of combined administration of probiotics and a recombinant protein containing an extracellular domain of an alpha subunit of an IgE Fc receptor. Therefore, it is expected that the composition is highly industrially applicable due to being able to exhibit a remarkable therapeutic effect on an IgE-mediated allergic disease as compared with conventional pharmaceutical compositions.

公开(公告)号：US20240350567A1

公开(公告)日：2024-10-24

申请号：US18579158

申请日：2022-07-15

申请人： Alfasigma S.p.A.

发明人： Andrea Biffi ,  Walter Fiore

IPC分类号： A61K35/747 ,  A61K35/745 ,  A61K45/06 ,  A61P1/00

CPC分类号： A61K35/747 ,  A61K35/745 ,  A61K45/06 ,  A61P1/00

摘要： The present invention relates to at least one strain of bacteria belonging to the species Lactobacillus paracasei, preferably Lactobacillus paracasei DG® CNCM I-1572 and/or Lactobacillus paracasei LPC-01 DSM 26760, and compositions thereof for use in newborns and/or from 1 month to ≤12 months subjects in the treatment, preventive and/or curative, of gastro-intestinal tract disorders of an inflammatory and/or functional nature, gastro-intestinal infections by pathogenic micro-organisms, gastro-intestinal infections by parasites, allergies, immune-mediated or autoimmune disorders, and in the support of the subject's growth.

公开(公告)号：US20240350564A1

公开(公告)日：2024-10-24

申请号：US18302922

申请日：2023-04-19

申请人： Yu-Lin Yang

发明人： Yu-Lin Yang

IPC分类号： A61K35/745 ,  A61K35/747 ,  A61K36/287 ,  A61K36/41 ,  A61K36/42 ,  A61K36/48 ,  A61K36/537 ,  A61K36/605 ,  A61K36/73 ,  A61K36/736 ,  A61P39/00

CPC分类号： A61K35/745 ,  A61K35/747 ,  A61K36/287 ,  A61K36/41 ,  A61K36/42 ,  A61K36/48 ,  A61K36/537 ,  A61K36/605 ,  A61K36/73 ,  A61K36/736 ,  A61P39/00 ,  A61K2035/115

摘要： A composition with NRF mitochondria activating ingredient has telomere extension, anti-aging and cell-rejuvenating effects, including salvia miltiorrhiza extract, wheat α-amylase inhibitor, and probiotic powder. After taken by users, the composition reaches a health effect by extending the telomere length and to reduce the cell age and get younger.

公开(公告)号：US20240335487A1

公开(公告)日：2024-10-10

申请号：US18609015

申请日：2024-03-19

申请人： Unique Biotech Limited

发明人： Ratna Sudha Madempudi ,  Manoj Pandurang Dandekar ,  Manisurya Kumar Palepu ,  Srilakshmi Satya Satti

IPC分类号： A61K35/747 ,  A61K31/198 ,  A61K35/742 ,  A61K35/745 ,  A61P25/24

CPC分类号： A61K35/747 ,  A61K31/198 ,  A61K35/742 ,  A61K35/745 ,  A61P25/24

摘要： Multi-strain probiotic formulation for ameliorating and preventing symptoms of treatment resistant depression
The current invention more specifically relates to methods and compositions comprising a multi-strain probiotic formulation that can be used for alleviating symptoms of treatment-resistant depression in humans.
The multi-strain probiotic formulation disclosed herein for use as treatment for treatment-resistant depression symptoms comprises Bacillus coagulans, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium breve, and Bifidobacterium infantis. More specifically, the multi-strain probiotic formulation comprises Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, Bifidobacterium breve UBBr-01, and Bifidobacterium infantis UBBI-01.

公开(公告)号：US12110486B2

公开(公告)日：2024-10-08

申请号：US18146706

申请日：2022-12-27

申请人： MORINAGA MILK INDUSTRY CO., LTD.

发明人： Toshitaka Odamaki ,  Kumiko Kato

IPC分类号： C12N1/20 ,  A23L2/52 ,  A23L33/00 ,  A23L33/125 ,  A23L33/135 ,  A61K35/745 ,  A61K47/26 ,  A61K47/36 ,  A61K35/00

CPC分类号： C12N1/20 ,  A23L2/52 ,  A23L33/125 ,  A23L33/135 ,  A23L33/40 ,  A61K35/745 ,  A61K47/26 ,  A61K47/36 ,  A23V2002/00 ,  A23V2400/533 ,  A61K2035/115

摘要： Provide are beneficial bacteria that can be beneficially applied across a wide range of age groups and a composition containing the same. Bifidobacterium longum subspecies longum NITE BP-02568 and/or Bifidobacterium longum subspecies longum NITE BP-02569; and Bifidobacterium longum subspecies longum, having utilization ability for 2′-fucosyllactose are also provided. More preferably, bacteria having utilization ability for carbohydrates arabinoxylan, arabinan, and pectic galactan; and a composition containing the bacteria are also provided. More preferably, a composition containing 2′-fucosyllactose are also provided. More preferably, a composition containing at least one carbohydrate selected from the group consisting of arabinoxylan, arabinan, pectic galactan, and oligosaccharides derived therefrom or containing at least a carbohydrate derived from a gramineous plant or a carbohydrate derived from a solanaceous plant are also provided.

公开(公告)号：US20240293485A1

公开(公告)日：2024-09-05

申请号：US18572429

申请日：2022-06-21

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： SAMI DAMAK ,  MARC GARCIA-GARCERA ,  BERNARD BERGER ,  FABIO MAINARDI ,  CLARA LUCIA GARCIA-RODENAS ,  SHAILLAY KUMAR DOGRA

IPC分类号： A61K35/747 ,  A61K31/702 ,  A61K31/717 ,  A61K31/732 ,  A61K31/736 ,  A61K35/00 ,  A61K35/745 ,  A61K36/42 ,  A61K36/55 ,  A61K36/736 ,  A61P1/14

CPC分类号： A61K35/747 ,  A61K31/702 ,  A61K31/717 ,  A61K31/732 ,  A61K31/736 ,  A61K35/745 ,  A61K36/42 ,  A61K36/55 ,  A61K36/736 ,  A61P1/14 ,  A61K2035/115

摘要： A composition contains a combination of at least one fiber and at least one probiotic and is formulated for administration to a subject such that the combination of at least one fiber and at least one probiotic enhance resilience of the microbiome in the subject. Preferably the subject is experiencing a microbiome stressor, will experience a microbiome stressor and/or has recently experienced a microbiome stressor, such as one or more of a dietary stressor, antibiotic, other medications, infections, intense exercise, stress, alcohol, travel and combinations thereof; more preferably at least a dietary stressor; most preferably at least a high fat diet, such as a Western high fat diet or a ketogenic diet. The method can achieve at least one result that is (i) prevention or attenuation of perturbation of microbiota; (ii) recovery after perturbation; and (iii) normalization of one or more of stool frequency, intestinal transit, constipation, gut permeability, endotoxemia or gut barrier function.

公开(公告)号：US12075808B2

公开(公告)日：2024-09-03

申请号：US17601316

申请日：2020-03-31

申请人： COREE S.R.L.

发明人： Marina Elli ,  Chong-Yoon Lim

IPC分类号： A23L7/104 ,  A23L33/00 ,  A23L33/135 ,  A61K9/00 ,  A61K35/745 ,  A61K35/747

CPC分类号： A23L7/104 ,  A23L33/135 ,  A23L33/40 ,  A61K9/0056 ,  A61K35/745 ,  A61K35/747 ,  A23V2002/00 ,  A23V2400/145 ,  A23V2400/175 ,  A23V2400/519

摘要： A fermented food product or food supplement comprising a vegetable substrate fermented by a probiotic blend is disclosed. The fermented food product or food supplement according to the invention is useful in particular for improving natural maternity, lactation and baby weaning. The invention also discloses a process for the preparation of the fermented food product or food supplement comprising the fermentation of a vegetal substrate with the probiotic blend.

公开(公告)号：US20240285516A1

公开(公告)日：2024-08-29

申请号：US18652326

申请日：2024-05-01

申请人： IIAA Limited

发明人： Lorraine PERRETTA ,  Paul NAUDE ,  Tanya MEYER

IPC分类号： A61K8/99 ,  A61K8/67 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61Q5/00 ,  A61Q19/00

CPC分类号： A61K8/99 ,  A61K8/676 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61Q5/002 ,  A61Q19/00

摘要： The present invention relates to a composition comprising at least one probiotic strain of bacteria and at least one postbiotic strain of bacteria. The present invention also relates to a method of improving the appearance skin and/or hair, and a method of altering the microbiome of the skin of a subject, wherein the method comprises orally administering said composition to a subject in need thereof.

公开(公告)号：US20240277781A1

公开(公告)日：2024-08-22

申请号：US18569805

申请日：2022-06-21

申请人： Pendulum Therapeutics, Inc.

发明人： John S. Eid ,  Paul J. McMurdie ,  Orville G. Kolterman

IPC分类号： A61K35/742 ,  A61K9/00 ,  A61K35/00 ,  A61K35/741 ,  A61K35/745 ,  A61K45/06 ,  A61P1/16

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61K35/741 ,  A61K35/745 ,  A61K45/06 ,  A61P1/16 ,  A61K2035/115

摘要： Provided are methods of increasing ursodeoxycholic acid (UDCA) levels in a mammalian subject. The methods comprise orally administering to the mammalian subject a composition comprising one or more bacterial strains in an amount effective to increase UDCA levels in the mammalian subject. Also provided are methods of antagonizing farnesoid X receptor (FXR) in intestinal cells of a mammalian subject. Such methods comprise orally administering to the mammalian subject a composition comprising one or more bacterial strains in an amount effective to antagonize FXR in intestinal cells of the mammalian subject. In certain embodiments, the mammalian subject has diabetes, e.g., type 2 diabetes. According to some embodiments, the mammalian subject suffers from a liver disorder, obesity, or both. In certain embodiments, the mammalian subject has colorectal cancer. According to some embodiments, the mammalian subject has gallstones.

公开(公告)号：US20240261347A1

公开(公告)日：2024-08-08

申请号：US17796553

申请日：2021-01-29

申请人： PROAGNI PTY LTD ,  AUSTRIANOVA SINGAPORE PTE LTD

发明人： Athol Victor Klieve ,  Fiona Eileen Soulsby ,  Robert James Bell ,  Lachlan Ian Campbell ,  John Austin Dangerfield

IPC分类号： A61K35/747 ,  A23K10/16 ,  A23K20/116 ,  A23K20/163 ,  A23K40/25 ,  A23K40/30 ,  A61K9/48 ,  A61K35/745 ,  A61P3/00

CPC分类号： A61K35/747 ,  A23K10/16 ,  A23K20/116 ,  A23K20/163 ,  A23K40/25 ,  A23K40/30 ,  A61K9/4816 ,  A61K9/4833 ,  A61K35/745 ,  A61P3/00

摘要： The present disclosure relates generally to encapsulated strict obligate anaerobic bacteria, (e.g., Megasphaera eldesdenii and Ruminicoccus bromi), compositions comprising same, and the use of said capsules and/or compositions to deliver the strict obligate anaerobic bacteria to the gastrointestinal tract (GI) of an animal, such as a livestock animal (e.g., a ruminant or hindgut fermenter). The present disclosure relates to the encapsulation of strict obligate anaerobic bacteria which utilize lactic acid and/or starch and the use of those encapsulated bacteria in the field of animal health and nutrition. In particular examples, the present disclosure utilises porous capsules comprising surface pores with a molecular weight cut off between 50 and 200 kDa and wall comprising a complex formed from sodium cellulose sulphate and poly [dimethyldially-ammonium chloride].