公开(公告)号：US20080205724A1

公开(公告)日：2008-08-28

申请号：US11911216

申请日：2006-04-11

申请人： Christian Adrian Cocosco ,  Wiro Joep Niessen ,  Thomas Netsch

发明人： Christian Adrian Cocosco ,  Wiro Joep Niessen ,  Thomas Netsch

IPC分类号： G06K9/00

CPC分类号： G06K9/342 ,  G06K2009/366 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10072 ,  G06T2207/20092 ,  G06T2207/20132 ,  G06T2207/30048

摘要： The method 1 according to the invention is preferably practiced in real time and directly after a suitable acquisition 3 of the multi-dimensional dataset, which is accessed at step 5 and the images constituting the multi-dimensional dataset are classified at step 8. Preferably, for reducing an amount of data to be processed at step 6 the image data is subjected to a restrictive region of interest determination. At step 9 the classified cardiac images are subjected to a an image thinning operator so that the resulting images comprise a plurality of connected image components which are further analyzed at step 14. After the thinning step 9 a labeling step 11 is performed, where different connected components in the multi-dimensional dataset are accordingly labeled. This step is preferably followed by a region growing step 13, which is constrained by binary threshold used at step 8b. For each connected image component a factor F is computed at step 14. The anatomic structure is segmented at step 16 by selecting the connected image component with factor F meeting a pre-determined criterion. After this, the segmented anatomic structure is stored in a suitable format at step 18. The invention further relates to an apparatus, a working station, a viewing station and a computer program.

摘要翻译： 根据本发明的方法1优选地实时地并且直接在多维数据集的合适的获取3之后实施，该多维数据集在步骤5被访问，并且构成多维数据集的图像在步骤8被分类。 优选地，为了减少在步骤6处理的数据量，图像数据经受限制性关注区域确定。 在步骤9，对分类的心脏图像进行图像稀疏算子，使得所得到的图像包括在步骤14进一步分析的多个连接图像分量。 在变薄步骤9之后，执行标记步骤11，其中相应地标记多维数据集中不同的连接分量。 该步骤优选地是区域生长步骤13，其由在步骤8b使用的二进制阈值约束。 对于每个连接的图像分量，在步骤14计算因子F. 通过选择具有满足预定标准的因子F的连接图像分量，在步骤16分割解剖结构。 之后，分段的解剖结构以适当的格式存储在步骤18。 本发明还涉及一种装置，工作站，观察站和计算机程序。

公开(公告)号：US20090010505A1

公开(公告)日：2009-01-08

申请号：US11909165

申请日：2006-03-21

申请人： Christian Adrian Cocosco ,  Thomas Netsch

发明人： Christian Adrian Cocosco ,  Thomas Netsch

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/30048

摘要： The method (1) according to the invention may be schematically divided into three major phases. Phase (2) comprises step (3) of acquiring a suitable dataset, which is then subjected to a suitable binary segmentation at step (4) results of which are being accessed at step (5). The results comprise temporally sequenced binary coded images, whereby image portions corresponding to blood are labeled as unity, the rest is set to zero. The subsequent phase (12) of the method according to the invention is directed to performing the image processing for segmenting a structure. At step (8) a computation is performed whereby a preceding binary coded image (8a) corresponding to a phase from the temporal sequence is subtracted from a subsequent binary coded image 8b corresponding to a phase yielding a multi-dimensional temporal feature map (8c). At step (9) spatial positions corresponding to a certain voxel value are derived and are used to segment the structure. A pre-defined deformable shape model is accessed at step (11), which is then deformed at step (14) in accordance with spatial coordinates, derived at step (9). Preferably, the segmentation result is stored at step (16). Finally, during a further phase (22) of the method according to the invention, the segmentation results are displayed at step (18) using suitable display means. Preferably, the segmented surface is overlaid on the original data using a two, three or four-dimensional visualization technique. Still preferable, to ease comprehension of the result, the segmented surface is presented as a color-code in a suitable transparency mode. The invention further relates to an apparatus and a computer program for segmenting a structure in a dataset.

摘要翻译： 根据本发明的方法（1）可以示意性地分为三个主要阶段。 阶段（2）包括步骤（3），获取合适的数据集，然后在步骤（4）对其结果进行适当的二进制分段，结果在步骤（5）被访问。 结果包括时间排序的二进制编码图像，由此对应于血液的图像部分被标记为一体，其余部分被设置为零。 根据本发明的方法的后续阶段（12）涉及执行用于分割结构的图像处理。 在步骤（8），进行计算，由此从对应于产生多维时间特征图（8c）的相位的后续二进制编码图像8b中减去对应于来自时间序列的相位的先前二进制编码图像（8a） 。 在步骤（9），导出与某个体素值对应的空间位置，并用于分割结构。 在步骤（11）访问预定义的可变形形状模型，然后在步骤（14）根据在步骤（9）导出的空间坐标变形。 优选地，在步骤（16）存储分割结果。 最后，在根据本发明的方法的另一阶段（22）期间，使用合适的显示装置在步骤（18）显示分割结果。 优选地，使用二，三或四维可视化技术将分割的表面覆盖在原始数据上。 仍然优选的是，为了简化对结果的理解，分段表面以适当的透明度模式呈现为颜色代码。 本发明还涉及用于分割数据集中的结构的装置和计算机程序。

公开(公告)号：US08144987B2

公开(公告)日：2012-03-27

申请号：US11911128

申请日：2006-04-13

申请人： Christian Adrian Cocosco ,  Stewart Young ,  Thomas Netsch ,  Michael Kaus

发明人： Christian Adrian Cocosco ,  Stewart Young ,  Thomas Netsch ,  Michael Kaus

IPC分类号： G06K9/00 ,  G06K9/34

CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30048

摘要： A method is arranged to segment a surface in a multi-dimensional dataset comprising a plurality of images. Data processing and data acquisition steps can be temporally or geographically distanced, so that the results of a suitable data segmentation are accessed. Next, suitable plurality of image features resembling possible spatial positions of the surface conceived to be segmented are selected and accessed. The features are subsequently matched for all image portions, whereby for each feature a matching error is assigned. A pre-defined selectivity factor is accessed defining a maximum allowable variable fraction of the features having largest matching errors which can be discarded. The segmentation of the sought surface is performed, whereby the discarded features are not taken into account for evaluating the quality of fit of a candidate deformation. The resulting surface is displayed on a suitable display means.

摘要翻译： 布置一种在包括多个图像的多维数据集中对表面进行分割的方法。 数据处理和数据采集步骤可以在时间上或地理上远离，以便访问合适的数据分段的结果。 接下来，选择并访问类似于被分割的表面的可能的空间位置的合适的多个图像特征。 这些特征随后对于所有图像部分进行匹配，由此为每个特征分配匹配误差。 访问预定义的选择性因子，定义可以丢弃具有最大匹配误差的特征的最大允许可变分数。 执行所寻求的表面的分割，由此不考虑丢弃的特征来评估候选变形的拟合质量。 所得到的表面显示在合适的显示装置上。

公开(公告)号：US20080285821A1

公开(公告)日：2008-11-20

申请号：US12067842

申请日：2006-09-07

申请人： Christian Adrian Cocosco ,  Thomas Netsch ,  Daniel Bystrov ,  Stewart Young

发明人： Christian Adrian Cocosco ,  Thomas Netsch ,  Daniel Bystrov ,  Stewart Young

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T7/11 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/20081 ,  G06T2207/30004

摘要： The invention relates to a method 1 of image segmentation where in step 2 a prior model representative of a structure conceived to be segmented in an image is accessed. Preferably, the image comprises a medical diagnostic image. Still preferably, the medical diagnostic image is prepared in a DICOM format, whereby supplementary information is stored besides diagnostic data. In these cases the method 1 according to the invention advantageously proceeds to step 3, where the supplementary information is extracted from electronic file 5, comprising for example suitable patient-related information 5a and/or suitable structure-related information 5b. Examples of the patient-related information comprise a patient's age, sex, group, etc., whereas examples of the structure-related information may comprise an anatomic location of the structure, such as rectum, bladder, lung etc, or the suspected/diagnosed pathology of the patient. In an alternative embodiment of the method 1 according to the invention, the supplementary information is provided by a human operator in step 7, where he can enter suitable supplementary information 9a, 9b using a user interface 9. When the supplementary information is loaded, the method 1 according to the invention proceeds to step 4 in which the prior model is being changed using the supplementary information yielding a further model. In step 6 the method 1 performs the image segmentation using the thus obtained further model and in step 8 the results of the segmentation step may be visualized on a suitable viewer.

摘要翻译： 本发明涉及一种图像分割的方法1，其中在步骤2中，访问了代表在图像中被分割的结构的先前模型。 优选地，图像包括医学诊断图像。 更优选地，以DICOM格式准备医疗诊断图像，除了诊断数据之外还存储补充信息。 在这些情况下，根据本发明的方法1有利地进行到步骤3，其中从电子文件5中提取补充信息，包括例如适合的患者相关信息5a和/或合适的结构相关信息5b。 患者相关信息的示例包括患者的年龄，性别，组等，而结构相关信息的实例可以包括结构的解剖位置，例如直肠，膀胱，肺等或疑似/诊断的 患者病理。 在根据本发明的方法1的替代实施例中，补充信息由人类操作者在步骤7中提供，在那里他可以使用用户界面9输入合适的补充信息9a，9b。 当加载补充信息时，根据本发明的方法1进行到步骤4，在步骤4中，使用产生另外的模型的补充信息来改变现有模型。 在步骤6中，方法1使用由此获得的另外的模型执行图像分割，并且在步骤8中，分割步骤的结果可以在合适的观看者上可视化。

公开(公告)号：US08320652B2

公开(公告)日：2012-11-27

申请号：US11909165

申请日：2006-03-21

申请人： Christian Adrian Cocosco ,  Thomas Netsch

发明人： Christian Adrian Cocosco ,  Thomas Netsch

IPC分类号： G06K9/00 ,  G06K9/34

CPC分类号： G06T7/0012 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/30048

摘要： A suitable database, including a temporal series of images is acquired (3) and subjected to a suitable binary segmentation (4) to create temporally sequenced binary coded images large portions corresponding to blood are labeled as unity, the rest is set to zero. A preceding binary coded image (8a) corresponding to a phase (t) from the temporal sequence is subtracted from a subsequent binary coded image (8b) corresponding to a phase (t+1) yielding a multi-dimensional temporal feature map (8c). A pre-defined deformable shape model is deformed (14) to fit the temporal feature map. The segmentation results are displayed (18) using suitable display (47). The segmented surface is overlaid on the original data using a two-, three- or four-dimensional visualization technique and can be presented as a color-code in a suitable transparency mode.

摘要翻译： 获取包括时间序列图像的合适的数据库（3）并进行合适的二进制分割（4）以创建时间排序的二进制编码图像，对应于血液的大部分被标记为1，其余的被设置为零。 从对应于产生多维时间特征图（8c）的相位（t + 1）的后续二进制编码图像（8b）中减去对应于来自时间序列的相位（t）的前一二进制编码图像（8a） 。 预定义的可变形形状模型被变形（14）以适应时间特征图。 使用合适的显示（47）显示分割结果（18）。 使用二维，三维或四维可视化技术将分割的表面覆盖在原始数据上，并且可以以适当的透明度模式呈现为颜色代码。

公开(公告)号：US20090060319A1

公开(公告)日：2009-03-05

申请号：US11911128

申请日：2006-04-13

申请人： Christian Adrian Cocosco ,  Stewart Young ,  Thomas Netsch ,  Michael Kaus

发明人： Christian Adrian Cocosco ,  Stewart Young ,  Thomas Netsch ,  Michael Kaus

IPC分类号： G06K9/00 ,  G06K9/34

CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30048

摘要： The method according to the invention is arranged to segment a surface in a multi-dimensional dataset comprising a plurality of images, which may be acquired using a suitable data-acquisition unit at a preparatory step 2. It is possible that data processing and data acquisition steps are temporally or geographically distanced, so that at step 4 the results of a suitable data segmentation step 6 are accessed, whereby said results comprise portions of the image which are subsequently used to segment the surface using the method of the invention. Next, at step 8 a suitable plurality of image features resembling possible spatial positions of the surface conceived to be segmented are selected and accessed. The features are subsequently matched for all image portions at step 10, whereby for each feature a matching error is assigned. At step 14 a pre-defined selectivity factor is accessed defining a maximum allowable variable fraction of the features having largest matching errors which can be discarded. The segmentation of the sought surface is performed at step 16, whereby the discarded features are not taken into account for evaluating the quality of fit of a candidate deformation of the. The resulting surface is being displayed on a suitable display means at step 18, whereby it is preferably overlaid on original, notably diagnostic data for user's analysis. In case when the user is satisfied with the result of the segmentation, the segmented surface is stored at step 18. Otherwise, the process is returned to step 14, where a further selectivity factor is accessed. It is possible that the further selectivity factor is altered at step 11 by a user's input, or, alternatively it may be provided by a certain alteration algorithm 13. The invention further relates to a system, a computer program, a workstation, a viewing station, a computer program and a user interface.

摘要翻译： 根据本发明的方法被布置为在包括多个图像的多维数据集中分割表面，所述多个图像可以在准备步骤2使用合适的数据获取单元获取。可能的是，数据处理和数据采集 步骤在时间上或地理上是间距的，使得在步骤4中，访问合适的数据分割步骤6的结果，由此所述结果包括随后用于使用本发明的方法分割表面的图像的部分。 接下来，在步骤8中，选择并访问类似于被分割的表面的可能的空间位置的合适的多个图像特征。 随后在步骤10对所有图像部分匹配特征，由此为每个特征分配匹配误差。 在步骤14，访问预定义的选择性因子，定义可以丢弃具有最大匹配误差的特征的最大允许可变分数。 在步骤16执行所寻求的表面的分割，由此不考虑丢弃的特征来评估候选变形的拟合质量。 在步骤18，所得到的表面被显示在合适的显示装置上，由此优选地覆盖在原始的，特别是用于用户分析的诊断数据上。 在用户对分割结果满意的情况下，在步骤18存储分割曲面。否则，该过程返回到步骤14，其中进一步选择性因子被访问。 在步骤11，用户的输入可以改变另外的选择性因素，或者也可以由某个改变算法13提供。本发明还涉及系统，计算机程序，工作站，观察台 ，计算机程序和用户界面。

公开(公告)号：US20100061632A1

公开(公告)日：2010-03-11

申请号：US12516357

申请日：2007-11-26

申请人： Stewart Young ,  Daniel Bystrov ,  Thomas Netsch ,  Michael Kaus ,  Vladimir Pekar

发明人： Stewart Young ,  Daniel Bystrov ,  Thomas Netsch ,  Michael Kaus ,  Vladimir Pekar

IPC分类号： G06K9/34 ,  G06K9/46

CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T7/70 ,  G06T2207/30016

摘要： The invention relates to a method for data processing. At stage 3 the position of the reference object in the reference image and its relation to a set of reference landmarks in the reference image is established at step 6. In order to enable this, the reference imaging of learning examples may be performed at step 2 and each reference image may be analyzed at step 4, the results may be stored in a suitably arranged database. In order to process the image under consideration, the image is accessed at step 11, the suitable landmark corresponding to the reference landmark in the reference image is identified at step 13 and the spatial relationship established at step 6 is applied to the landmark thereby providing the initial position of the object in the actual image. In case when for the object an imaging volume is selected, the method 1 according to the invention follows to step 7, whereby the scanning 17 is performed within the boundaries given by the thus established scanning volume. In case when for the object a model representative of the target is selected, the method 1 follows to the image segmentation step 19, whereby a suitable segmentation is performed. In case when for the model a deformable model is selected, the segmentation is performed by deforming the model thereby providing spatial boundaries of the target area. The invention further relates to an apparatus and a computer program for image processing.

摘要翻译： 本发明涉及一种数据处理方法。 在阶段3，在步骤6中建立参考图像中的参考对象的位置及其与参考图像中的一组参考标记的关系。为了实现这一点，可以在步骤2执行学习示例的参考成像 并且可以在步骤4分析每个参考图像，结果可以存储在适当布置的数据库中。 为了处理所考虑的图像，在步骤11访问图像，在步骤13识别与参考图像中的参考标记相对应的合适地标，并将在步骤6建立的空间关系应用于地标，从而提供 物体在实际图像中的初始位置。 在对于物体选择成像体积的情况下，根据本发明的方法1遵循步骤7，由此在由这样建立的扫描体积给出的边界内执行扫描17。 在针对对象的情况下，选择了表示目标的模型，则对图像分割步骤19进行方法1，由此执行适当的分割。 在为模型选择可变形模型的情况下，通过使模型变形从而提供目标区域的空间边界来执行分割。 本发明还涉及一种用于图像处理的装置和计算机程序。

公开(公告)号：US20080069418A1

公开(公告)日：2008-03-20

申请号：US11814406

申请日：2006-01-05

申请人： Daniel Bystrov ,  Vladimir Pekar ,  Kirsten Meetz ,  Thomas Netsch ,  Stewart Young

发明人： Daniel Bystrov ,  Vladimir Pekar ,  Kirsten Meetz ,  Thomas Netsch ,  Stewart Young

IPC分类号： G06K9/00

CPC分类号： G06T13/20 ,  G06T7/246 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30048

摘要： In a diagnostic imaging system (10), a user interface (82) facilitates viewing of 4D kinematic data sets. A set of reference points is selected in a first 3D image to designate an anatomical component. An algorithm (104) calculates a propagation of the selected reference points from the first 3D image into other 3D images. Transforms which describe the propagation of the reference points between 3D images are defined. An aligning algorithm (112) applies inverse of the transforms to the 3D images to define a series of frames for the video processor (120) to display, in which frames the designated anatomical component defined by the reference points in each of the 3D images remains fixed while the other portions of the anatomical region of interest move relative to the fixed designated anatomical component.

摘要翻译： 在诊断成像系统（10）中，用户界面（82）便于观看4D运动数据集。 在第一3D图像中选择一组参考点以指定解剖组件。 算法（104）计算所选择的参考点从第一3D图像到其他3D图像的传播。 定义描述3D图像之间参考点传播的变换。 对准算法（112）将变换的逆向应用于3D图像以定义用于视频处理器（120）显示的一系列帧，其中由每个3D图像中的参考点定义的指定解剖组件保留 固定，而感兴趣的解剖区域的其他部分相对于固定的指定解剖部件移动。

公开(公告)号：US20070195923A1

公开(公告)日：2007-08-23

申请号：US11568115

申请日：2005-03-31

申请人： Thomas Netsch ,  Georg Rose ,  Hermann Schomberg

发明人： Thomas Netsch ,  Georg Rose ,  Hermann Schomberg

IPC分类号： H05G1/60 ,  A61B6/00 ,  G01N23/00 ,  G21K1/12

CPC分类号： G06T11/005 ,  A61B6/027 ,  G06T2211/432 ,  Y10S378/901

摘要： A 3D image of a region of an object is computed from truncated cone beam projection data acquired with an x-ray device and a prior CT image representing a larger region of the object. The truncated projection data are extrapolated to derive pseudoprojection data associated with projection directions outside the detector, and an intermediate CT image is reconstructed based on the truncated projection data completed with the pseudoprojection data. The prior CT image is then registered with the intermediate CT image. Forward projection data associated with projection directions outside the detector are computed from the truncated projection data and the registered prior CT image. The 3D image is finally reconstructed based on the truncated projection data completed with the forward projection data.

摘要翻译： 使用由X射线装置获得的截头圆锥束投影数据和表示对象的较大区域的先前CT图像计算物体区域的3D图像。 外推截断的投影数据以导出与检测器外部的投影方向相关联的伪投影数据，并且基于用伪投影数据完成的截断的投影数据来重建中间CT图像。 然后将先前的CT图像与中间CT图像对准。 从截断的投影数据和注册的先前CT图像计算与检测器外部的投影方向相关联的前向投影数据。 基于用前向投影数据完成的截断的投影数据，最终重建3D图像。

公开(公告)号：US20070133849A1

公开(公告)日：2007-06-14

申请号：US10595694

申请日：2004-11-02

申请人： Stewart Young ,  Thomas Netsch

发明人： Stewart Young ,  Thomas Netsch

IPC分类号： G06K9/00

CPC分类号： G06T15/20 ,  G06T15/08 ,  G06T19/00 ,  G06T2210/41 ,  G06T2215/06

摘要： The present invention relates to a method and a corresponding apparatus for visualization of a tubular structure of an object by use of a 3D image data set of said object. In order to provide a more efficient and illustrative visualization a method is proposed comprising the steps of: —generating and visualising a curved planar reformation view (C) from a symbolic pathway view (B) of said tubular structure, said symbolic pathway view (B) representing said tubular structure and the pathway points of said symbolic pathway being assigned with their 3D spatial position data, and —generating and visualising at least one planar view (O) of said object (1) through a viewing point (V) of said tubular structure selected in said curved planar reformation view (C) or said symbolic pathway view (B).

摘要翻译： 本发明涉及一种通过使用所述对象的3D图像数据集可视化对象的管状结构的方法和相应的装置。 为了提供更有效和说明性的可视化，提出了一种方法，其包括以下步骤： - 从所述管状结构的符号通路图（B）产生和可视化曲面平面重构视图（C），所述符号通路视图（B ），并且所述符号路径的路径点被分配有它们的3D空间位置数据，并且通过所述管状结构的观察点（V）生成和可视化所述物体（1）的至少一个平面视图（O） 在所述弯曲平面重构视图（C）或所述符号通路视图（B）中选择的管状结构。