摘要:
The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要:
The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要:
Water soluble prodrugs of rapamycin are disclosed which are useful as components in injectable pharmaceutical formulations for the treatment of tumors in mammals.
摘要:
A method of treating a person for sickle cell anemia including administering to the patient's blood a therapeutically effective dosage of ethacrynic acid. The dosage may be administered to blood removed from the patient which blood after addition of the compound is restored to the patient or by other means such as orally.
摘要:
A process for the recovery of hydrocarbon vapors from an air-hydrocarbon mixture wherein the inlet air-hydrocarbon mixture is passed to an absorber vessel in which is fed a vacuum flashed liquid hydrocarbon absorbent to produce an absorber overhead gas stream which is passed to a solid absorbent bed. Once saturated, the adsorbed hydrocarbon on the solid adsorbent bed is removed by liquid vacuum pump regeneration, separated from the pump liquid, and returned to the system for use. Hydrocarbon free air is vented from the solid adsorbent bed during the adsorption mode.
摘要:
A process for the recovery of hydrocarbon vapors from an air-hydrocarbon mixture expelled as a result of storage breathing or loading of a vented hydrocarbon vessel. An inlet air-hydrocarbon mixture is passed to a first absorber in which is fed a vacuum flashed liquid hydrocarbon absorbent to produce a first absorber overhead gas which is passed to a solid absorbent bed. Once saturated, the absorbed hydrocarbon on the solid absorbent is removed by vacuum regeneration, separated from liquid supplied by the liquid ring pump creating the vacuum, and passed to a second absorber vessel where fresh liquid hydrocarbon absorbent is contacted therewith to produce a second absorber overhead gas which is combined with the incoming inlet air-hydrocarbon mixture to pass therewith to the first absorber. Hydrocarbon free air is vented from the solid absorbent bed during the adsorption mode.
摘要:
A Fischer-Tropsch-based hydrocarbon conversion process involves compressing air in a compressor section of a gas turbine, delivering a portion of the compressed air to a combustor of the gas turbine, delivering a portion of the compressed air to a Fischer-Tropsch hydrocarbon conversion unit, extracting thermal energy from the combustor and delivering it to the Fischer-Tropsch hydrocarbon conversion unit, converting light hydrocarbons into heavier hydrocarbons in the Fischer-Tropsch hydrocarbon conversion unit, and delivering combustion gases from the combustor to an expansion section of the gas turbine. A heat recovery steam generator (HRSG) may also be used to harness waste heat from the expansion section. A conversion system for converting light hydrocarbons into heavier hydrocarbons includes a turbine from which heat energy is removed and used to assist in converting hydrocarbons and whereby greater throughput of the turbine is possible. Waste heat from the expander of the turbine may be recovered with a HRSG.
摘要:
A Fischer-Tropsch-based hydrocarbon conversion process involves compressing air in a compressor section of a gas turbine, delivering a portion of the compressed air to a combustor of the gas turbine, delivering a portion of the compressed air to a Fischer-Tropsch hydrocarbon conversion unit, extracting thermal energy from the combustor and delivering it to the Fischer-Tropsch hydrocarbon conversion unit, converting light hydrocarbons into heavier hydrocarbons in the Fischer-Tropsch hydrocarbon conversion unit, and delivering combustion gases from the combustor to an expansion section of the gas turbine. A heat recovery steam generator (HRSG) may also be used to harness waste heat from the expansion section. A conversion system for converting light hydrocarbons into heavier hydrocarbons includes a turbine from which heat energy is removed and used to assist in converting hydrocarbons and whereby greater throughput of the turbine is possible. Waste heat from the expander of the turbine may be recovered with a HRSG.
摘要:
The present invention relates to a sterile, stable vacuum dried crystalline amifostine composition and, optionally, pharmaceutically acceptable excipient(s). Typically, the crystalline compositions of the present invention exhibit enhanced stability at temperatures ranging from about 4.degree. C. to about ambient temperature for a period of at least 2 years relative to existing solid vacuum dried amorphous amifostine preparations. The reconstituted compositions of the present invention are suitable for administration to humans as a radio- or chemoprotecting agent.
摘要:
The present invention relates to a sterile, stable vacuum dried crystalline amifostine composition and, optionally, pharmaceutically acceptable excipient(s). Typically, the crystalline compositions of the present invention exhibit enhanced stability at temperatures ranging from about 4.degree. C. to about ambient temperature for a period of at least 2 years relative to existing solid vacuum dried amorphous amifostine preparations. The reconstituted compositions of the present invention are suitable for administration to humans as a radio- or chemoprotecting agent.