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公开(公告)号：US20130034559A1
公开(公告)日：2013-02-07
申请号：US13511538
申请日：2010-11-24
申请人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30 , C12N15/13 , C12N5/10
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed
摘要翻译： 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外，公开了表达这种抗体的杂交瘤或其它细胞系
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公开(公告)号：US08779108B2
公开(公告)日：2014-07-15
申请号：US13511538
申请日：2010-11-24
申请人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
发明人： Christophe Queva , Michelle Morrow , Scott Hammond , Marat Alimzhanov , John Babcook , Ian Nevin Foltz , Jaspal Singh Kang , Laura Sekirov , Melanie Boyle , Matthieu Chodorge , Ross A. Stewart , Kathleen Ann Mulgrew
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.
摘要翻译： 公开了针对B7-H1的人单克隆抗体以及这些抗体在诊断中的用途以及用于治疗与B7-H1的活性和/或表达相关的疾病的疾病。 此外，公开了表达这种抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20070014720A1
公开(公告)日：2007-01-18
申请号：US11440728
申请日：2006-05-25
IPC分类号： A61K51/00 , A61K39/395 , C07H21/04 , C12P21/06 , C07K16/28
CPC分类号： C07K16/2887 , A61K51/1027 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Antibodies directed to the antigen CD20 and uses of such antibodies are disclosed herein. In particular, fully human monoclonal antibodies directed to the antigen CD20. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.
摘要翻译： 本文公开了针对抗原CD20的抗体和这种抗体的用途。 特别是针对抗原CD20的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 被披露。 还公开了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20110129412A1
公开(公告)日：2011-06-02
申请号：US11916163
申请日：2006-05-25
申请人： Gadi Gazit-Bornstein , Larry J. Green , Xiao-Dong Yang , Christophe Queva , David Clarles Blakey , Mohammad Tabrizi
发明人： Gadi Gazit-Bornstein , Larry J. Green , Xiao-Dong Yang , Christophe Queva , David Clarles Blakey , Mohammad Tabrizi
CPC分类号： C07K16/2887 , A61K51/1027 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Antibodies directed to the antigen CD20 and uses of such antibodies are disclosed herein. In particular, fully human monoclonal antibodies directed to the antigen CD20. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.
摘要翻译： 本文公开了针对抗原CD20的抗体和这种抗体的用途。 特别是针对抗原CD20的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 被披露。 还公开了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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