公开(公告)号：US20160311779A1

公开(公告)日：2016-10-27

申请号：US15032872

申请日：2014-10-29

申请人： Christopher ADAMS ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Toshio KAWANAMI ,  Nello MAINOLFI ,  James J. POWERS ,  Michael SERRANO-WU ,  Chun ZHANG ,  Rajeshri Ganesh KARKI

发明人： Christopher ADAMS ,  Takeru EHARA ,  Keith JENDZA ,  Nan JI ,  Rajeshri Ganesh KARKI ,  Toshio KAWANAMI ,  Nello MAINOLFI ,  James POWERS ,  Michael Serrano-WU ,  Chun ZHANG

IPC分类号： C07D235/12 ,  C07D235/14

CPC分类号： C07D235/12 ,  A61K31/4184 ,  A61K45/06 ,  C07D235/14 ,  A61K2300/00

摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式（I）化合物，其用于制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US20210378293A1

公开(公告)日：2021-12-09

申请号：US17340954

申请日：2021-06-07

申请人： Christopher ADAMS ,  Giovanni MIONE ,  R.Y.L. Inc.

发明人： Christopher ADAMS ,  Giovanni MIONE

IPC分类号： A24D3/18 ,  A24D3/10 ,  A24D3/16

摘要： A system including a pre-roll cone or cylinder used as a sleeve for use with smokeable substances, a tip for being attached to a sleeve for holding a smokeable substance. The tip has a freshness plug at a first end of the tip and a filter at a second end of the tip. The sleeve can be formed using with papers made from a variety of materials. Smoking papers are cut in a way to form sleeves that attach to the larger end of the glass tip, or the end where the tip meets raw material. The use of sleeves allows for the re-use of tips made from materials capable of multiple uses without degradation of quality, such as glass or metal. The filter has a cross-hair or similar shape at the end adjacent to the smokeable substance. The freshness plug is at the other end of the tip.