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    Organic compounds
    2.
    发明授权
    Organic compounds 有权
    有机化合物

    公开(公告)号：US08497286B2

    公开(公告)日：2013-07-30

    申请号：US13616081

    申请日：2012-09-14

    申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    IPC分类号： A61K31/444 ,  C07D211/32

    CPC分类号： C07D401/12

    摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

    摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。

    Substituted Piperdines as Renin Inhibitors
    9.
    发明申请
    Substituted Piperdines as Renin Inhibitors 审中-公开
    取代喋呤作为肾素抑制剂

    公开(公告)号：US20090137566A1

    公开(公告)日：2009-05-28

    申请号：US11914869

    申请日：2006-05-24

    申请人： Takeru Ehara ,  Yuko Hitomi ,  Kazuhide Konishi ,  Kelichi Masuya

    发明人： Takeru Ehara ,  Yuko Hitomi ,  Kazuhide Konishi ,  Kelichi Masuya

    IPC分类号： A61K31/5415 ,  A61K31/538 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/454 ,  C07D417/02 ,  C07D413/02 ,  C07D405/02 ,  C07D409/02

    CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14

    摘要： The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds preferably have the formula I, wherein the moieties R1, R2, R11 and W are as defined in the specification.

    摘要翻译： 本发明涉及取代的3,4-或更高级取代的哌啶化合物，其用于制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 药物制剂或包含所述化合物的产品，和/或包括给药所述化合物的方法，制备所述化合物的方法，以及新型中间体，起始材料和/或其合成的部分步骤。 化合物优选具有式I，其中部分R1，R2，R11和W如说明书中所定义。

    ORGANIC COMPOUNDS
    10.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20080319018A1

    公开(公告)日：2008-12-25

    申请号：US12146073

    申请日：2008-06-25

    申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

    发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

    IPC分类号： A61K31/4545 ,  C07D401/12 ,  A61P43/00

    CPC分类号： C07D401/12

    摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

    摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。