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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
申请人： Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC分类号： A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US10448989B2
公开(公告)日：2019-10-22
申请号：US13332133
申请日：2011-12-20
摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US20170266438A1
公开(公告)日：2017-09-21
申请号：US15310114
申请日：2015-05-12
申请人： Michael B. SANO , Christopher B. ARENA , Scott S. VERBRIDGE , Rafael V. DAVALOS , Virginia Tech Intellectual Properties, Inc.
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US08465484B2
公开(公告)日：2013-06-18
申请号：US12609779
申请日：2009-10-30
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。 在实施方案中，所述方法包括使用具有或不具有改性表面化学性质的高纵横比纳米颗粒。
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5.发明授权Integration of very short electric pulses for minimally to noninvasive electroporation 有权将非常短的电脉冲集成到非侵入性电穿孔中公开(公告)号：US08926606B2
公开(公告)日：2015-01-06
申请号：US12757901
申请日：2010-04-09
CPC分类号： A61N1/327 , A61B18/1477 , A61B2018/0016 , A61B2018/00613 , A61N1/0412 , A61N1/0424
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.
摘要翻译： 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）或超处理，以在治疗的肿瘤中引起细胞死亡。 在实施例中，这些方法包括在时间和空间上集成超短电脉冲以实现所需的细胞死亡模式。
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