公开(公告)号：US20060179496A1

公开(公告)日：2006-08-10

申请号：US11190172

申请日：2005-07-26

申请人： Christopher Burgess ,  Jon Astle ,  Eddie Carroll ,  Theodore Catino ,  Poornima Dwivedi ,  Gary Molino ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lawrence Burgart ,  Lisa Boardman

发明人： Christopher Burgess ,  Jon Astle ,  Eddie Carroll ,  Theodore Catino ,  Poornima Dwivedi ,  Gary Molino ,  Arunthathi Thiagalingam ,  Marcia Lewis ,  Stephen Thibodeau ,  Lawrence Burgart ,  Lisa Boardman

IPC分类号： A01K67/027 ,  C07K14/82 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06

CPC分类号： G01N33/6893 ,  A01K2217/05 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57419 ,  G01N2500/00

摘要： This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue.

摘要翻译： 本发明涉及在癌细胞中差异表达的新型核酸序列。 本发明还涉及由序列编码的蛋白质和肽，基于序列和蛋白质的诊断测定和治疗剂，以及衍生自序列和蛋白质或肽的探针，反义构建体和抗体。 已经发现目标核酸被肿瘤细胞差异表达，特别是在结肠癌组织中。