公开(公告)号：US08466281B2

公开(公告)日：2013-06-18

申请号：US13124884

申请日：2009-10-15

申请人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

发明人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

IPC分类号： C07D265/30 ,  A61K31/535

CPC分类号： A61K31/445 ,  C07D265/28 ,  C07D413/10 ,  C07D413/14

摘要： The present invention is directed to 2,5-disubstituted morpholine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的吗啉酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

公开(公告)号：US20110312961A1

公开(公告)日：2011-12-22

申请号：US13124884

申请日：2009-10-15

申请人： Christopher D. Cox ,  Paul J. Coleman ,  Broc Flores ,  John D. Schreier

发明人： Christopher D. Cox ,  Paul J. Coleman ,  Broc Flores ,  John D. Schreier

IPC分类号： A61K31/5377 ,  A61P25/00 ,  C07D413/14

CPC分类号： A61K31/445 ,  C07D265/28 ,  C07D413/10 ,  C07D413/14

摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).

摘要翻译： 本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种各样的病症和疾病的方法， 包括与中枢神经系统（CNS）功能障碍相关的那些。

公开(公告)号：US08357700B2

公开(公告)日：2013-01-22

申请号：US13125191

申请日：2009-10-15

申请人： Christopher D. Cox ,  Broc Flores ,  John D. Schreier

发明人： Christopher D. Cox ,  Broc Flores ,  John D. Schreier

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D401/14

摘要： The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,3-二取代哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

公开(公告)号：US20110263643A1

公开(公告)日：2011-10-27

申请号：US13125191

申请日：2009-10-15

申请人： Christopher D. Cox ,  Broc Flores ,  John D. Schreier

发明人： Christopher D. Cox ,  Broc Flores ,  John D. Schreier

IPC分类号： A61K31/4545 ,  A61P25/20 ,  A61K31/4709 ,  C07D401/14 ,  A61K31/4725

CPC分类号： C07D401/14

摘要： The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,3-二取代哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。