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    2,5-disubstituted morpholine orexin receptor antagonists
    1.
    发明授权
    2,5-disubstituted morpholine orexin receptor antagonists 有权
    2,5-二取代吗啉食欲肽受体拮抗剂

    公开(公告)号：US08466281B2

    公开(公告)日：2013-06-18

    申请号：US13124884

    申请日：2009-10-15

    申请人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

    发明人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

    IPC分类号： C07D265/30 ,  A61K31/535

    CPC分类号： A61K31/445 ,  C07D265/28 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention is directed to 2,5-disubstituted morpholine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的吗啉酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    2,4-Disubstituted Pyrrolidine Orexin Receptor Antagonists
    8.
    发明申请
    2,4-Disubstituted Pyrrolidine Orexin Receptor Antagonists 有权
    2,4-二取代吡咯烷矿物蛋白受体拮抗剂

    公开(公告)号：US20110201652A1

    公开(公告)日：2011-08-18

    申请号：US13124877

    申请日：2009-10-15

    申请人： Christopher D. Cox ,  Paul J. Coleman ,  John D. Schreier

    发明人： Christopher D. Cox ,  Paul J. Coleman ,  John D. Schreier

    IPC分类号： A61K31/4439 ,  C07D401/14 ,  A61P25/00

    CPC分类号： C07D401/14

    摘要： The present invention is directed to 2,4-disubstituted pyrrolidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,4-二取代的吡咯烷酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Pyridyl piperidine orexin receptor antagonists
    10.
    发明授权
    Pyridyl piperidine orexin receptor antagonists 有权
    吡啶基哌啶食欲素受体拮抗剂

    公开(公告)号：US08569311B2

    公开(公告)日：2013-10-29

    申请号：US13568242

    申请日：2012-08-07

    申请人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  John D. Schreier

    发明人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  John D. Schreier

    IPC分类号： C07D401/14 ,  A61K31/4525

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention is directed to pyridyl piperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶基哌啶化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。