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8 条记录 (耗时 0.213 秒)

    Compounds
    1.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号：US6100059A

    公开(公告)日：2000-08-08

    申请号：US70526

    申请日：1998-04-30

    申请人： Christopher Donald Southan ,  Helen Elizabeth Clinkenbeard ,  Nicola Anne Burgess

    发明人： Christopher Donald Southan ,  Helen Elizabeth Clinkenbeard ,  Nicola Anne Burgess

    IPC分类号： G01N33/15 ,  A61K31/70 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P43/00 ,  C07K16/40 ,  C12N9/64 ,  C12N15/09 ,  C12N15/57 ,  C12P21/02

    CPC分类号： C12N9/6424 ,  A61K38/00 ,  A61K39/00

    摘要： HGBAB90 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HGBAB90 polypeptides and polynucleotides in the design of protocols for the treatment of pulmonary emphysema, arthritis, multiple sclerosis, periodontal disease, cystic fibrosis, respiratory disease, thrombosis, cancer, cachexia, angina, glaucoma, inflamatory disorders, osteoporosis, cardiovascular disorders such as hypertension, atherosclerotic disorders such as cardiac infarction, and stroke, asthma, psoriasis, chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, demyelinating diseases, AIDS immune deficiency, disorders of photoreceptor degeneration, and lens cataract formation, organ transplant rejection, cataracts, restenosis, muscular dystrophy, renal failure, cerebral vasospasm, pancreatitis, and diabetic nephropathy, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了通过重组技术生产此类多肽的HGBAB90多肽和多核苷酸和方法。 还公开了在设计用于治疗肺气肿，关节炎，多发性硬化，牙周病，囊性纤维化，呼吸道疾病，血栓形成，癌症，恶病质，心绞痛，青光眼，炎症性疾病，骨质疏松症的方案中使用HGBAB90多肽和多核苷酸的方法 心血管疾病如心脏梗死和中风，哮喘，牛皮癣，慢性神经变性疾病如阿尔茨海默病，帕金森氏症和亨廷顿舞蹈症，脱髓鞘疾病，艾滋病免疫缺陷症，光感受器变性障碍和晶状体白内障形成等心血管疾病， 器官移植排斥，白内障，再狭窄，肌营养不良，肾衰竭，脑血管痉挛，胰腺炎和糖尿病肾病等，以及这些病症的诊断测定。

    Protein involved in ovarian cancer
    5.
    发明授权
    Protein involved in ovarian cancer 有权
    涉及卵巢癌的蛋白质

    公开(公告)号：US08263071B2

    公开(公告)日：2012-09-11

    申请号：US12587870

    申请日：2009-10-14

    申请人： Nicola Anne Burgess

    发明人： Nicola Anne Burgess

    IPC分类号： A61K39/395

    CPC分类号： C07K16/3069 ,  A61K38/1709 ,  C12Q1/6886 ,  G01N33/689

    摘要： The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including vaccines, antibodies that are immunospecific for CDCP1 and agents which interact with or modulate the expression or activity of CDCP1 or which modulate the expression of the nucleic acid which codes for CDCP1.

    摘要翻译： 本发明涉及CDCP1在卵巢癌诊断，筛选，治疗和预防中的新用途。 本发明还提供包含CDCP1的组合物，包括疫苗，针对CDCP1免疫特异性的抗体和与CDCP1的表达或活性相互作用或调节CDCP1的表达或活性或调节编码CDCP1的核酸表达的试剂。

    Protein involved in ovarian cancer
    6.
    发明申请
    Protein involved in ovarian cancer 有权
    涉及卵巢癌的蛋白质

    公开(公告)号：US20110059088A1

    公开(公告)日：2011-03-10

    申请号：US12587870

    申请日：2009-10-14

    申请人： Nicola Anne Burgess

    发明人： Nicola Anne Burgess

    IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K39/44 ,  A61P35/00 ,  G01N33/53

    CPC分类号： C07K16/3069 ,  A61K38/1709 ,  C12Q1/6886 ,  G01N33/689

    摘要： The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including vaccines, antibodies that are immunospecific for CDCP1 and agents which interact with or modulate the expression or activity of CDCP1 or which modulate the expression of the nucleic acid which codes for CDCP1.

    摘要翻译： 本发明涉及CDCP1在卵巢癌诊断，筛选，治疗和预防中的新用途。 本发明还提供包含CDCP1的组合物，包括疫苗，针对CDCP1免疫特异性的抗体和与CDCP1的表达或活性相互作用或调节CDCP1的表达或活性或调节编码CDCP1的核酸表达的试剂。

    Protein involved in ovarian cancer
    7.
    发明授权
    Protein involved in ovarian cancer 有权
    涉及卵巢癌的蛋白质

    公开(公告)号：US09120860B2

    公开(公告)日：2015-09-01

    申请号：US13566011

    申请日：2012-08-03

    申请人： Nicola Anne Burgess

    发明人： Nicola Anne Burgess

    IPC分类号： G01N33/574 ,  G01N33/53 ,  C07K16/30 ,  A61K38/17 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C07K16/3069 ,  A61K38/1709 ,  C12Q1/6886 ,  G01N33/689

    摘要： The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including vaccines, antibodies that are immunospecific for CDCP1 and agents which interact with or modulate the expression or activity of CDCP1 or which modulate the expression of the nucleic acid which codes for CDCP1.

    摘要翻译： 本发明涉及CDCP1在卵巢癌诊断，筛选，治疗和预防中的新用途。 本发明还提供包含CDCP1的组合物，包括疫苗，针对CDCP1免疫特异性的抗体和与CDCP1的表达或活性相互作用或调节CDCP1的表达或活性或调节编码CDCP1的核酸表达的试剂。

    Protein Involved in Ovarian Cancer
    8.
    发明申请
    Protein Involved in Ovarian Cancer 有权
    蛋白质涉及卵巢癌

    公开(公告)号：US20130230524A1

    公开(公告)日：2013-09-05

    申请号：US13566011

    申请日：2012-08-03

    申请人： Nicola Anne Burgess

    发明人： Nicola Anne Burgess

    IPC分类号： C07K16/30 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： C07K16/3069 ,  A61K38/1709 ,  C12Q1/6886 ,  G01N33/689

    摘要： The present invention relates to new uses of CDCP1 in the diagnosis, screening, treatment and prophylaxis of ovarian cancer. The invention also provides compositions comprising CDCP1, including vaccines, antibodies that are immunospecific for CDCP1 and agents which interact with or modulate the expression or activity of CDCP1 or which modulate the expression of the nucleic acid which codes for CDCP1.

    摘要翻译： 本发明涉及CDCP1在卵巢癌诊断，筛选，治疗和预防中的新用途。 本发明还提供包含CDCP1的组合物，包括疫苗，针对CDCP1免疫特异性的抗体和与CDCP1的表达或活性相互作用或调节CDCP1的表达或活性或调节编码CDCP1的核酸表达的试剂。