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    Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same
    1.
    发明授权
    Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same 失效
    含有全氟化合物用于移植细胞和组织工程改进细胞新陈代谢和存活的聚合物制剂及其制备方法

    公开(公告)号：US06630154B1

    公开(公告)日：2003-10-07

    申请号：US09477466

    申请日：2000-01-04

    申请人： Christopher Fraker ,  Luca Inverardi ,  Marcos Mares-Guia ,  Camillo Ricordi

    发明人： Christopher Fraker ,  Luca Inverardi ,  Marcos Mares-Guia ,  Camillo Ricordi

    IPC分类号： A61F202

    CPC分类号： A61K31/734 ,  A61K31/02 ,  A61K31/715 ,  A61K31/726 ,  A61K45/06 ,  C08B37/0069 ,  C08B37/0084 ,  C08K5/02 ,  C08L5/04 ,  C08L5/08 ,  A61K2300/00 ,  C08L2666/26 ,  C08L2666/02

    摘要： Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as “paints”, sprays, matrices, beads, microcapsules.

    摘要翻译： 公开和要求保护的是：包含至少一种葡糖胺聚糖（例如CIS），至少一种全氟化物质和至少一种藻酸盐（例如海藻酸钠）的组合物，其中：至少一种糖胺聚糖和/或全氟化物质和/或 海藻酸盐是交联或聚合的，例如藻酸盐是交联或聚合的，例如通过加入无机盐如钙盐; 或至少一种糖胺聚糖，全氟化物质和藻酸盐共价结合，例如通过涉及连接分子如DVS的偶联反应; 或至少一种糖胺聚糖和/或全氟化物质和/或藻酸盐进行交联或聚合，例如藻酸盐被交联或聚合，例如通过加入无机盐如钙盐和 所述至少一种葡糖胺聚糖和藻酸盐是共价结合的，例如通过涉及连接分子如DVS的偶联反应，并且共价结合可以在交联或聚合之前进行，反之亦然; 和包含该组合物的凝胶; 这种凝胶或至少一种此类凝胶和至少一种此类组合物的混合物; 以及制造和使用这些组合物和凝胶（包括其产品）如“油漆”，喷雾剂，基质，珠粒，微胶囊的方法。

    Enhanced Oxygen Cell Culture Platforms
    3.
    发明申请
    Enhanced Oxygen Cell Culture Platforms 有权
    增强氧细胞培养平台

    公开(公告)号：US20080009027A1

    公开(公告)日：2008-01-10

    申请号：US11775012

    申请日：2007-07-09

    申请人： Christopher Fraker ,  Juan Dominguez-Bendala ,  Ricordi Camillo ,  Luca Inverardi

    发明人： Christopher Fraker ,  Juan Dominguez-Bendala ,  Ricordi Camillo ,  Luca Inverardi

    IPC分类号： C12Q1/02 ,  C12N1/00 ,  C12N5/06

    CPC分类号： C12M23/12 ,  C12M23/04 ,  C12M23/20 ,  C12M23/24 ,  C12M25/04

    摘要： Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the rapid, enhanced and uniform transfer of oxygen between the environment of cells or tissues contained in the cell culture container apparatus and the atmosphere of the incubator in which the cell culture apparatus is incubated.

    摘要翻译： 本发明提供了一种用于培养细胞的细胞培养装置，其提供增强的氧输送和供应到细胞而不需要搅拌或喷射。 氧扩散发生在培养容器的两侧，顶部和底部。 在其组成中包含全氟化碳的气体渗透膜允许在细胞培养容器装置中包含的细胞或组织的环境和细胞培养装置孵育的培养箱的气氛之间快速，增强和均匀地转移氧气 。