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    Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same
    1.
    发明授权
    Polymer formulations containing perfluorinated compounds for the engineering of cells and tissues for transplantation that improves cell metabolism and survival, and methods for making same 失效
    含有全氟化合物用于移植细胞和组织工程改进细胞新陈代谢和存活的聚合物制剂及其制备方法

    公开(公告)号：US06630154B1

    公开(公告)日：2003-10-07

    申请号：US09477466

    申请日：2000-01-04

    申请人： Christopher Fraker ,  Luca Inverardi ,  Marcos Mares-Guia ,  Camillo Ricordi

    发明人： Christopher Fraker ,  Luca Inverardi ,  Marcos Mares-Guia ,  Camillo Ricordi

    IPC分类号： A61F202

    CPC分类号： A61K31/734 ,  A61K31/02 ,  A61K31/715 ,  A61K31/726 ,  A61K45/06 ,  C08B37/0069 ,  C08B37/0084 ,  C08K5/02 ,  C08L5/04 ,  C08L5/08 ,  A61K2300/00 ,  C08L2666/26 ,  C08L2666/02

    摘要： Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as “paints”, sprays, matrices, beads, microcapsules.

    摘要翻译： 公开和要求保护的是：包含至少一种葡糖胺聚糖（例如CIS），至少一种全氟化物质和至少一种藻酸盐（例如海藻酸钠）的组合物，其中：至少一种糖胺聚糖和/或全氟化物质和/或 海藻酸盐是交联或聚合的，例如藻酸盐是交联或聚合的，例如通过加入无机盐如钙盐; 或至少一种糖胺聚糖，全氟化物质和藻酸盐共价结合，例如通过涉及连接分子如DVS的偶联反应; 或至少一种糖胺聚糖和/或全氟化物质和/或藻酸盐进行交联或聚合，例如藻酸盐被交联或聚合，例如通过加入无机盐如钙盐和 所述至少一种葡糖胺聚糖和藻酸盐是共价结合的，例如通过涉及连接分子如DVS的偶联反应，并且共价结合可以在交联或聚合之前进行，反之亦然; 和包含该组合物的凝胶; 这种凝胶或至少一种此类凝胶和至少一种此类组合物的混合物; 以及制造和使用这些组合物和凝胶（包括其产品）如“油漆”，喷雾剂，基质，珠粒，微胶囊的方法。

    Hetero-polysaccharide conjugate and methods of making and using the same
    2.
    发明授权
    Hetero-polysaccharide conjugate and methods of making and using the same 失效
    杂多糖缀合物及其制备和使用方法

    公开(公告)号：US06281341B1

    公开(公告)日：2001-08-28

    申请号：US08877682

    申请日：1997-06-17

    申请人： Marcos Mares-Guia ,  Camillo Ricordi

    发明人： Marcos Mares-Guia ,  Camillo Ricordi

    IPC分类号： C08B3704

    CPC分类号： A61L27/3804 ,  A61K9/1652 ,  A61K9/5073 ,  A61K9/70 ,  A61L17/145 ,  C08B37/0084 ,  C08L5/04 ,  C08L2666/02

    摘要： Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and, gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and, methods for making and using such compositions and gels, including products therefrom such as “paints”, sprays, matrices, beads, microcapsules.

    摘要翻译： 公开和要求保护的是：包含至少一种葡糖胺聚糖（例如CIS）和至少一种藻酸盐（例如海藻酸钠）的组合物，其中：所述至少一种葡糖胺聚糖和/或所述组合物是交联或聚合的，例如 藻酸盐是交联或聚合的，例如通过加入无机盐如钙盐; 或至少一种糖胺聚糖和藻酸盐共价结合，例如通过涉及连接分子例如DVS的偶联反应; 或所述至少一种糖胺聚糖和/或所述组氨酸被交联或聚合，例如藻酸盐被交联或聚合，例如通过加入无机盐例如钙盐，和所述至少一种糖胺聚糖和 海藻酸盐是共价结合的，例如通过涉及连接分子如DVS的偶联反应，共价结合可以在交联或聚合之前进行，反之亦然; 和包含该组合物的凝胶; 这种凝胶或至少一种此类凝胶和至少一种此类组合物的混合物; 以及制造和使用这些组合物和凝胶（包括其产品）如“油漆”，喷雾剂，基质，珠粒，微胶囊的方法。

    Organ transportation device
    7.
    发明授权
    Organ transportation device 有权
    器官运输装置

    公开(公告)号：US07790437B2

    公开(公告)日：2010-09-07

    申请号：US11610913

    申请日：2006-12-14

    申请人： Ramon E. Poo ,  Camillo Ricordi

    发明人： Ramon E. Poo ,  Camillo Ricordi

    IPC分类号： A01N1/00 ,  A01N1/02 ,  C12M1/00 ,  C12M3/00

    CPC分类号： A01N1/02 ,  A01N1/0273

    摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.

    摘要翻译： 器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。 提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。 基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。

    MOBILE EMERGENCY ALERT SYSTEM
    8.
    发明申请
    MOBILE EMERGENCY ALERT SYSTEM 审中-公开
    移动应急报警系统

    公开(公告)号：US20080166992A1

    公开(公告)日：2008-07-10

    申请号：US11938057

    申请日：2007-11-09

    申请人： Camillo Ricordi ,  Steven Sikes ,  Stephen William Anthony Sanders

    发明人： Camillo Ricordi ,  Steven Sikes ,  Stephen William Anthony Sanders

    IPC分类号： H04M11/04 ,  H04M3/42 ,  H04Q7/00

    CPC分类号： H04M11/04 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/024 ,  A61B5/14532 ,  A61B5/1455 ,  G08B21/0269 ,  G08B21/0283 ,  G08B21/0453 ,  G08B25/002 ,  G08B25/005 ,  G08B25/006 ,  G08B25/08 ,  H04M1/72538

    摘要： A health-related emergency mobile alert system to facilitate communication, care and intervention during critical events. The system communicates with medical monitors, which measure and collect a subject's physiological data and vital signs information. A service provider maintains a database with the subject's medical records and an emergency contact list. When a critical event is detected, a two-way mobile communication device that is configured to communicate with the medical monitor transmits the physiological data and location coordinates of the subject to the service provider, and a conference call with members of the emergency contact list is initiated to help facilitate aid to the subject. The two-way mobile communication device may include a speaker and GPS technology. It may also include self-activating features wherein pre-recorded messages conveying potential dangers are transmitted to the subject when the subject's physiological data and vital signs reflect precarious levels.

    摘要翻译： 健康相关的紧急移动警报系统，以促进关键事件期间的沟通，关怀和干预。 系统与医疗监护仪进行通信，医疗监护仪可测量和收集受试者的生理数据和生命体征信息。 服务提供商维护与受试者的医疗记录和紧急联系人列表的数据库。 当检测到关键事件时，被配置为与医疗监视器通信的双向移动通信设备将该对象的生理数据和位置坐标发送给服务提供商，并且与紧急联系人列表的成员的电话会议是 开始帮助促进对该问题的援助。 双向移动通信设备可以包括扬声器和GPS技术。 它还可以包括自我激活特征，其中当被摄体的生理数据和生命体征反映不稳定的水平时，传达潜在危险的预先记录的信息被传送给受检者。

    ORGAN TRANSPORTATION DEVICE
    9.
    发明申请
    ORGAN TRANSPORTATION DEVICE 有权
    有机运输装置

    公开(公告)号：US20080145833A1

    公开(公告)日：2008-06-19

    申请号：US11610913

    申请日：2006-12-14

    申请人： RAMON E. POO ,  Camillo Ricordi

    发明人： RAMON E. POO ,  Camillo Ricordi

    IPC分类号： A01N1/00 ,  A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0273

    摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.

    摘要翻译： 器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。 提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。 基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。

    Organ preservation container and method
    10.
    发明申请
    Organ preservation container and method 有权
    器官保鲜容器及方法

    公开(公告)号：US20060121437A1

    公开(公告)日：2006-06-08

    申请号：US11003808

    申请日：2004-12-03

    申请人： Ramon Poo ,  Camillo Ricordi

    发明人： Ramon Poo ,  Camillo Ricordi

    IPC分类号： A01N1/02 ,  A01N1/00

    CPC分类号： A01N1/02 ,  A01N1/0263

    摘要： An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.

    摘要翻译： 器官保存容器包括用于容纳器官的不透气壳体。 至少两种具有不同密度并形成液 - 液界面的液体也包含在壳体中。 提供用于密封壳体的封闭件。 在壳体内设置有用于接合器官并用于将器官的一部分保持在液 - 液界面处的结构，使得器官部分地保持在两液体中。 还描述了保存器官的方法。