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公开(公告)号：US5833705A
公开(公告)日：1998-11-10
申请号：US717285
申请日：1996-09-20
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译： 这是一种植入式血管闭塞装置。 通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。 本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。 拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。 该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。 该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。 外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。 血管闭塞性构件也可以用纤维编织物覆盖。 该装置通常通过导管引入身体。 该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。
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公开(公告)号：US6004338A
公开(公告)日：1999-12-21
申请号：US132117
申请日：1998-08-11
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase . The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译： 这是一种植入式血管闭塞装置。 通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。 本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。 拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。 该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。 该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。 外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。 血管闭塞性构件也可以用纤维编织物覆盖。 该装置通常通过导管引入身体。 该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。
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公开(公告)号：US6096034A
公开(公告)日：2000-08-01
申请号：US96806
申请日：1998-06-12
申请人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
发明人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B2017/12063 , A61F2002/30092 , A61F2210/0014 , A61F2250/0039 , A61F2310/00023
摘要： This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. The retaining device may be placed in the body temporarily or permanently. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium.
摘要翻译： 这是一种用于将人工闭塞装置植入和保持在与哺乳动物的体腔相邻并从其延伸的身体空间中的人造闭塞套件。 包括至少一个闭塞装置和用于阻挡闭塞装置移出闭塞部位的保持装置。 保持装置可以在靠近身体空间的保持位置处径向展开，以被阻塞到直径足以与保持位置处的身体腔壁接合并形成穿过要被遮挡的身体空间的入口区域的屏障。 扩张的保持装置还形成用于在保留位置处流过体腔的流明。 保持装置可以临时或永久地放置在身体中。 还可以在保持装置中设置至少一个半透入空间，从而允许将遮挡装置引入身体空间以被阻塞，但是防止闭塞装置随后从身体空间中移出。 这种半透入空间也可以是可扩张的，以允许通过其中的封闭装置的输送。 导引线或锥形输送导管可用于扩张可扩张空间并输送遮挡装置。 保持装置结构还可以包括在由镍和钛的超弹性合金制成的内芯构件上缠绕到主螺旋中的不透射线金属线。
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公开(公告)号：US5853418A
公开(公告)日：1998-12-29
申请号：US779451
申请日：1997-01-07
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprising a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member extending through the lumen formed, which stretch-resisting member is fixedly attached, directly or indirectly, to the coil in at least two locations. The stretch resisting member is preferably somewhat loose within the interior of the lumen so to prevent the coil from collapsing, binding, and therefore stiffening during passage of turns through the human body. The coil should bend easily. In some variations of the invention, the stretch-resisting member may be formed into coil tips at the ends of the coil using simple equipment such as soldering irons or the like. The tips are typically of the same diameter as is the coil body itself. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device may have a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. Desirably, the coil is extremely flexible and is controllaby released using a severable or mechanical joint such as an electrolytically detachable joint. External fibers may be attached to the device and affixed to the pre-formed linear member to increase thrombogenicity. The extremely flexible variation of the invention may be hydraulically delivered through the lumen of a catheter and is so flexible that it may be retrievably delivered therethrough a flow-directed catheter. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译： 这是一种植入式血管闭塞装置。 它通常是包括初级螺旋缠绕线圈的血管闭塞线圈，然后可以将其缠绕成次级形状。 本发明的中心在于在至少两个位置上使用延伸穿过形成的内腔的拉伸抵抗构件，该拉伸抵抗构件直接地或间接地固定到线圈上。 拉伸阻力构件优选地在内腔的内部稍微松动，从而防止线圈在匝穿过人体期间塌陷，结合并因此加强。 线圈应弯曲容易。 在本发明的一些变型中，可以使用诸如烙铁等的简单设备在线圈的端部处形成线圈尖端。 尖端通常具有与线圈体本身相同的直径。 该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。 该装置可以具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。 理想地，线圈非常柔软，并且使用可分离或机械接头（例如电解可拆卸接头）进行控制释放。 外部纤维可以附着到装置上并固定到预先形成的线性构件上以增加血栓形成。 本发明的极其灵活的变化可以通过导管的内腔液压输送，并且是如此柔性的，使得其可被可逆地递送通过其中的导向导管。 血管闭塞性构件也可以用纤维编织物覆盖。 该装置通常通过导管引入身体。 该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。
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公开(公告)号：US06168592A
公开(公告)日：2001-01-02
申请号：US09298357
申请日：1999-04-23
申请人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
发明人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
IPC分类号： A61M3100
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B2017/1205 , A61B2017/12063 , A61F2002/30092 , A61F2210/0014 , A61F2250/0039 , A61F2310/00023
摘要： This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.
摘要翻译： 这是一种用于将人工闭塞装置植入和保持在与哺乳动物的体腔相邻并从其延伸的身体空间中的人造闭塞套件。 包括至少一个闭塞装置和用于阻挡闭塞装置移出闭塞部位的保持装置。 保持装置可以在靠近身体空间的保持位置处径向展开，以被阻塞到直径足以与保持位置处的身体腔壁接合并形成穿过要被遮挡的身体空间的入口区域的屏障。 扩张的保持装置还形成用于在保留位置处流过体腔的流明。 还可以在保持装置中设置至少一个半透入空间，从而允许将遮挡装置引入身体空间以被阻塞，但是防止闭塞装置随后从身体空间中移出。 这种半透入空间也可以是可扩张的，以允许通过其中的封闭装置的输送。 导引线或锥形输送导管可用于扩张可扩张空间并输送遮挡装置。 保持装置结构还可以包括在由镍和钛的超弹性合金制成的内芯构件上缠绕到主螺旋中的不透射线金属线。 还提供了一种植入式医疗装置组件，其具有针对新型人造阻塞套件的保持装置所述的结构，并且经由电解可溶解的牺牲连接件连接到细长推动器。
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公开(公告)号：US5980514A
公开(公告)日：1999-11-09
申请号：US690183
申请日：1996-07-26
申请人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
发明人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B2017/1205 , A61B2017/12063 , A61F2002/30092 , A61F2210/0014 , A61F2250/0039 , A61F2310/00023
摘要： This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.
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公开(公告)号：US06344041B1
公开(公告)日：2002-02-05
申请号：US09699267
申请日：2001-10-26
申请人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
发明人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
IPC分类号： A61B1804
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B2017/1205 , A61B2017/12063 , A61F2002/30092 , A61F2210/0014 , A61F2250/0039 , A61F2310/00023
摘要： This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.
摘要翻译： 这是一种用于将人工闭塞装置植入和保持在与哺乳动物的体腔相邻并从其延伸的身体空间中的人造闭塞套件。 包括至少一个闭塞装置和用于阻挡闭塞装置移出闭塞部位的保持装置。 保持装置可以在靠近身体空间的保持位置处径向展开，以被阻塞到直径足以与保持位置处的身体腔壁接合并形成穿过要被遮挡的身体空间的入口区域的屏障。 扩张的保持装置还形成用于在保留位置处流过体腔的流明。 还可以在保持装置中设置至少一个半透入空间，从而允许将遮挡装置引入身体空间以被阻塞，但是防止闭塞装置随后从身体空间中移出。 这种半透入空间也可以是可扩张的，以允许通过其中的封闭装置的输送。 导引线或锥形输送导管可用于扩张可扩张空间并输送遮挡装置。 保持装置结构还可以包括在由镍和钛的超弹性合金制成的内芯构件上缠绕到主螺旋中的不透射线金属线。 还提供了一种植入式医疗装置组件，其具有针对新型人造阻塞套件的保持装置所述的结构，并且经由电解可溶解的牺牲连接件连接到细长推动器。
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公开(公告)号：US6033423A
公开(公告)日：2000-03-07
申请号：US974275
申请日：1997-11-19
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译： 这是一种植入式血管闭塞装置。 它是具有多个初级绕组次级层的复杂的螺旋卷绕线圈。 最终形状本质上通常是块状的，并且可以以解剖腔的近似形状使用。 它可以以球体，卵球形或其他变形的球形的近似形状部署。 该装置是由预先形成的线性血管闭塞构件制成的自形成形状。 纤维可以引入到装置上并固定到预成形的线性构件上。 构成部件也可以用纤维编织物覆盖。 该装置通常通过导管引入。 该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。 本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。
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公开(公告)号：US5749891A
公开(公告)日：1998-05-12
申请号：US779378
申请日：1997-01-07
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
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公开(公告)号：US06824553B1
公开(公告)日：2004-11-30
申请号：US09648378
申请日：2000-08-25
IPC分类号： A61M2900
CPC分类号： A61M25/005 , A61M25/0053 , A61M25/0054 , A61M2025/0081
摘要： This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
摘要翻译： 这是导管组件和导管组件的一部分。 该导管组件可用于进入体内的组织靶，通常是通过血管系统可接近的靶。 本发明的中心是使用位于导管主体内的编织金属加强构件，通常为超弹性合金带，以形成具有特别薄壁，受控刚度，高抗扭结性的导管，以及 从扭结情况完全恢复体内。 编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。 编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。 根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。 由于在刚性部分中存在刚性聚合物管或金属管或合成材料，所以导管组件的近端部分通常比较远的部分更坚硬。
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