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8 条记录 (耗时 0.017 秒)

    Processes and intermediates for the preparation of piperazine derivatives
    1.
    发明授权
    Processes and intermediates for the preparation of piperazine derivatives 失效
    制备哌嗪衍生物的方法和中间体

    公开(公告)号：US6133449A

    公开(公告)日：2000-10-17

    申请号：US12066

    申请日：1998-01-22

    申请人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    发明人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    IPC分类号： C07D213/74 ,  C07D401/12 ,  C07D419/04 ,  C07D213/42

    CPC分类号： C07D213/74 ,  C07D401/12 ,  C07D419/04

    摘要： Compounds having the formulaR.sup.5 O--A--NR.sup.4 --R.sup.2 (V)where R.sup.2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R.sup.4 and R.sup.5 are both hydrogen atoms or together represent --SO-- or --SO.sub.2 -- and A is C.sub.2 -C.sub.4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R.sup.4 and R.sup.5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI).R.sup.2 O--A--NH.sub.2 (VI)

    摘要翻译： 具有式R 5 O-A-NR 4 -R 2（V）的化合物，其中R 2是通过与氮原子相邻的碳原子连接到分子的其余部分的杂芳基，R 4和R 5都是氢原子或一起表示-SO-或 - SO 2 - 和A是任选被一个或多个低级烷基取代的C 2 -C 4亚烷基，作为制备作为末端化合物的药学上可用的哌嗪衍生物的新中间体。 具有式V的化合物，其中R 4和R 5是氢可以通过具有式（VI）的化合物的重排来制备：R 2 O-A-NH 2（VI）

    Oxathiazolidinyl pyridines
    2.
    发明授权
    Oxathiazolidinyl pyridines 失效
    氧杂氮烷基吡啶

    公开(公告)号：US06395902B1

    公开(公告)日：2002-05-28

    申请号：US09614792

    申请日：2000-07-12

    申请人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    发明人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    IPC分类号： C07D41904

    CPC分类号： C07D213/74 ,  C07D401/12 ,  C07D419/04

    摘要： Compounds having the formula R5O—A—NR4—R2  (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent —SO— or —SO2— and A is C2-C4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R4 and R5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI). R2O—A—NH2  (VI)

    摘要翻译： 具有通式R 2的化合物是通过与氮原子相邻的碳原子与分子的其余部分连接的杂芳基，并且R 4和R 5均为氢原子或一起代表-SO-或-SO 2 - 并且A为任选的C 2 -C 4亚烷基 被一个或多个低级烷基取代是制备药学上可用的哌嗪衍生物作为末端化合物的新中间体。 具有式V的化合物，其中R 4和R 5是氢可以通过具有式（VI）的化合物的重排来制备。

    Processes and intermediates for the preparation of piperazine derivatives
    3.
    发明授权
    Processes and intermediates for the preparation of piperazine derivatives 失效
    制备哌嗪衍生物的方法和中间体

    公开(公告)号：US06175012B1

    公开(公告)日：2001-01-16

    申请号：US09010741

    申请日：1998-01-22

    申请人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    发明人： Christopher Ian Brightwell ,  Robin Gerald Shepherd

    IPC分类号： C07D40112

    CPC分类号： C07D213/74 ,  C07D401/12 ,  C07D419/04

    摘要： Compounds having the formula R5O—A—NR4—R2  (V) where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent —SO— or —SO2— and A is C2-C4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R4 and R5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI). R2O—A—NH2  (VI)

    摘要翻译： 具有通式R 2的化合物是通过与氮原子相邻的碳原子与分子的其余部分连接的杂芳基，并且R 4和R 5均为氢原子或一起代表-SO-或-SO 2 - 并且A为任选的C 2 -C 4亚烷基 被一个或多个低级烷基取代是制备药学上可用的哌嗪衍生物作为末端化合物的新中间体。 具有式V的化合物，其中R 4和R 5是氢可以通过具有式（VI）的化合物的重排来制备。

    Phenanthridine derivatives and related compounds
    8.
    发明授权
    Phenanthridine derivatives and related compounds 失效
    菲啶衍生物及相关化合物

    公开(公告)号：US4046895A

    公开(公告)日：1977-09-06

    申请号：US651748

    申请日：1976-01-23

    申请人： Adrian Charles Ward Curran ,  Robin Gerald Shepherd

    发明人： Adrian Charles Ward Curran ,  Robin Gerald Shepherd

    IPC分类号： C07D221/12 ,  C07D221/16 ,  C07D215/48 ,  A61K31/47

    CPC分类号： C07D221/16 ,  C07D221/12

    摘要： The invention provides a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen or alkyl of 1-6 carbon atoms, R.sup.3 represents hydrogen, alkyl of 1-6 carbon atoms, or phenyl, X is Na, K, Li, or CSNHR.sup.4 wherein R.sup.4 is hydrogen or alkyl of 1-6 carbon atoms and n is 3, 4 or 5 or a pharmaceutically acceptacle acid addition salt of a compound where X is CSNHR.sup.4.The compounds of formula I wherein X is CSNHR.sup.4 are anti-ulcer agents. Those in which X is Na, K or Li are intermediates.

    摘要翻译： 本发明提供式I化合物（I）其中R 1和R 2相同或不同，表示氢或1-6个碳原子的烷基，R 3表示氢，1-6个碳原子的烷基或苯基， X是Na，K，Li或CSNHR 4，其中R 4是氢或1-6个碳原子的烷基，n是3,4或5，或其中X是CSNHR 4的化合物的药学上接受酸加成盐。