专利检索 ap:("Christopher J. Baldwin" OR "Conway C. Chang" OR "Binh T. Dang") AND inv:"Christopher J. Baldwin" 第 1 页

1.

发明授权
Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof 失效
标题翻译：多烯大环内酯类的水溶性酰胺衍生物及其制备及用途

公开(公告)号：US06664241B2

公开(公告)日：2003-12-16

申请号：US09870071

申请日：2001-05-29

申请人： Conway C. Chang , Binh T. Dang , Christopher J. Baldwin , David J. Loury , Reyna J. Simon , Robert R. Webb

发明人： Conway C. Chang , Binh T. Dang , Christopher J. Baldwin , David J. Loury , Reyna J. Simon , Robert R. Webb

IPC分类号： A61K3170

CPC分类号： C07H17/08

摘要： The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.

摘要翻译： 本发明提供两种新类型的可用于治疗或预防真菌感染的多烯大环内酯酰胺衍生物。新的多烯大环内酯酰胺衍生物表现出抗真菌活性，并且比常规多烯抗生素如两性霉素B和两性霉素B甲酯更具水溶性。

2.

发明授权
Derivatives of polyene macrolides and preparation and use thereof 失效

公开(公告)号：US06562796B2

公开(公告)日：2003-05-13

申请号：US10026853

申请日：2001-12-20

申请人： Christopher J. Baldwin , Conway C. Chang , Binh T. Dang

发明人： Christopher J. Baldwin , Conway C. Chang , Binh T. Dang

IPC分类号： A61K3170

CPC分类号： C07H17/08

摘要： The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.