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公开(公告)号：US08039460B2
公开(公告)日：2011-10-18
申请号：US11665523
申请日：2005-10-12
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
IPC分类号： A61P1/08 , A61P35/00 , A61K31/55 , C07D487/04 , C07D519/00
CPC分类号： C07D487/04
摘要： Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式（I）：和式（II）的化合物（其中变量R2，R4，A，B，D，W，X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或 预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08461185B2
公开(公告)日：2013-06-11
申请号：US12740098
申请日：2008-10-29
申请人： Christopher S. Burgey , Diem N. Nguyen , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
发明人： Christopher S. Burgey , Diem N. Nguyen , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： C07D413/14 , C07D261/04 , C07D261/08 , C07D261/20 , C07D263/32 , C07D413/04 , C07D413/12 , C07D417/14 , C07D487/04
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。
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公开(公告)号：US20080113966A1
公开(公告)日：2008-05-15
申请号：US11665523
申请日：2005-10-12
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , C07D498/04 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式（I）：和式（II）的化合物：（其中变量R 2，R 4，A，B，D，W，X，Y和Z分别为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20110003822A1
公开(公告)日：2011-01-06
申请号：US12740098
申请日：2008-10-29
IPC分类号： A61K31/495 , A61K31/501 , A61K31/4965 , A61K31/506 , A61K31/4436 , A61K31/444 , A61K31/422 , A61P25/20 , A61P29/00 , C07D471/00 , A61P25/00 , C07D413/14 , C07D413/12
CPC分类号： C07D413/14 , C07D261/04 , C07D261/08 , C07D261/20 , C07D263/32 , C07D413/04 , C07D413/12 , C07D417/14 , C07D487/04
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。
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公开(公告)号：US20110206783A1
公开(公告)日：2011-08-25
申请号：US13125935
申请日：2009-10-21
IPC分类号： A61K31/444 , C07D413/14 , A61K31/5377 , C07D401/12 , A61K31/4439 , C07D401/14 , A61K31/506 , C07D413/12 , C07D471/04 , A61K31/437 , C07D417/12 , C07D417/14 , A61K33/00 , A61K31/5513 , A61P25/04 , A61P25/20 , A61P25/08
CPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。
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公开(公告)号：US20080261972A1
公开(公告)日：2008-10-23
申请号：US11885926
申请日：2006-03-14
申请人： Daniel V. Paone , Diem N. Nguyen , Anthony W. Shaw , Christopher S. Burgey , Thomas J. Tucker , Samuel L. Graham
发明人： Daniel V. Paone , Diem N. Nguyen , Anthony W. Shaw , Christopher S. Burgey , Thomas J. Tucker , Samuel L. Graham
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/4545 , A61P25/06 , C07D401/14 , A61K31/497
CPC分类号： C07D401/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要： Compounds of Formula (I), (where variables R1, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式（I）化合物（其中变量R 1，A，B，W，X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080280857A1
公开(公告)日：2008-11-13
申请号：US12082233
申请日：2008-04-09
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07235545B2
公开(公告)日：2007-06-26
申请号：US11152537
申请日：2005-06-14
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： C07D401/14 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US07745427B2
公开(公告)日：2010-06-29
申请号：US11665943
申请日：2005-10-18
IPC分类号： C07D471/04 , C07D471/20 , A61K31/55 , A61P25/06
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）和式（II）的化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07534784B2
公开(公告)日：2009-05-19
申请号：US12082233
申请日：2008-04-09
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： C07D401/14 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y如本文所定义） CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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