公开(公告)号：US20110003822A1

公开(公告)日：2011-01-06

申请号：US12740098

申请日：2008-10-29

申请人： Christopher S. Burgey ,  Diem N. Nguyen ,  Daniel Paone ,  Craig M. Potteiger ,  Joseph P. Vacca

发明人： Christopher S. Burgey ,  Diem N. Nguyen ,  Daniel Paone ,  Craig M. Potteiger ,  Joseph P. Vacca

IPC分类号： A61K31/495 ,  A61K31/501 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/422 ,  A61P25/20 ,  A61P29/00 ,  C07D471/00 ,  A61P25/00 ,  C07D413/14 ,  C07D413/12

CPC分类号： C07D413/14 ,  C07D261/04 ,  C07D261/08 ,  C07D261/20 ,  C07D263/32 ,  C07D413/04 ,  C07D413/12 ,  C07D417/14 ,  C07D487/04

摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.

摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。

公开(公告)号：US20070287696A1

公开(公告)日：2007-12-13

申请号：US10587121

申请日：2005-01-25

申请人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Craig Stump ,  Theresa Williams

发明人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Craig Stump ,  Theresa Williams

IPC分类号： A61K31/551 ,  A61K31/454 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  A61P25/06 ,  C07D243/08 ,  C07D267/10 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.

摘要翻译： 式I化合物和式II化合物（其中R 1，R 2，R 3，R 4，R 4， >，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，药物组合物 包括这些化合物，使用这些化合物和组合物来预防或治疗涉及CGRP的疾病。

公开(公告)号：US20070225272A1

公开(公告)日：2007-09-27

申请号：US11724066

申请日：2007-03-14

申请人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/55 ,  C07D401/14

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060194783A1

公开(公告)日：2006-08-31

申请号：US10551830

申请日：2004-04-09

申请人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/554 ,  A61K31/55 ,  A61K31/553 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14

CPC分类号： C07D401/14 ,  C07D413/14

摘要： The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及用作CGRP拮抗剂的式I和式II化合物（其中变量R1，R2，R3，R4，R6，A，B，G，J，W，X和Y如本文所定义） 受体，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20050256098A1

公开(公告)日：2005-11-17

申请号：US11152537

申请日：2005-06-14

申请人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

发明人： Christopher Burgey ,  Zhengwu Deng ,  Diem Nguyen ,  Daniel Paone ,  Anthony Shaw ,  Theresa Williams

IPC分类号： A61K31/4188 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P25/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/00 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US20080090806A1

公开(公告)日：2008-04-17

申请号：US11665943

申请日：2005-10-18

申请人： Daniel Paone ,  Diem Nguyen ,  Christopher Burgey ,  James Deng

发明人： Daniel Paone ,  Diem Nguyen ,  Christopher Burgey ,  James Deng

IPC分类号： A61K31/55 ,  A61P25/00 ,  C07D471/04 ,  C07D471/20

CPC分类号： C07D471/04

摘要： The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式（I）和式（II）的化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070287697A1

公开(公告)日：2007-12-13

申请号：US11665520

申请日：2005-10-12

申请人： Daniel Paone ,  Anthony Shaw ,  Craig Potteiger

发明人： Daniel Paone ,  Anthony Shaw ,  Craig Potteiger

IPC分类号： A61K31/55 ,  A61K31/44 ,  A61K31/445 ,  A61K31/551 ,  A61P43/00 ,  C07D213/00 ,  C07D237/26 ,  C07D241/36 ,  C07D267/02 ,  C07D243/06 ,  C07D239/70 ,  C07D223/02 ,  C07D211/00 ,  A61K31/553 ,  A61K31/4985 ,  A61K31/519

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： Compounds of Formula (I) and Formula (II) (where variables R1, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式（I）和式（II）化合物（其中R 1，R 2，R 4，A，B，W， X，Y和Z如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。