公开(公告)号：US20050008553A1

公开(公告)日：2005-01-13

申请号：US10847995

申请日：2004-05-19

申请人： Christos Apostolidis ,  Bruno Brandalise ,  Ramon Carlos-Marquez ,  Willem Janssens ,  Roger Molinet ,  Tuomo Nikula

发明人： Christos Apostolidis ,  Bruno Brandalise ,  Ramon Carlos-Marquez ,  Willem Janssens ,  Roger Molinet ,  Tuomo Nikula

IPC分类号： A61K51/02 ,  A61K51/06 ,  A61K51/12 ,  G21G4/08 ,  G21G4/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  A61K51/06 ,  A61K51/1282

摘要： The invention relates to a method of loading a mother radionuclide into a radionuclide generator which comprises an cation exchange material, the said method comprising a preliminary step which consists in passing over said material a solution containing the mother radionuclide and a complexing agent for said radionuclide, said complexing agent being at an effective concentration so as to prevent the mother radionuclide from concentrating solely in one part of the volume of the cation exchange material, the cation exchange material being chosen in the group consisting of the macroporous resins and the resins having a crosslinking rate of from 1 to 12%. This method is applied to radioisotope generators which emit α particles and are used in particular in the field of radiotherapy.

摘要翻译： 本发明涉及一种将母体放射性核素装载到包含阳离子交换材料的放射性核素发生器中的方法，所述方法包括一个预备步骤，其中包括将含有母体放射性核素和所述放射性核素的络合剂的溶液通过所述材料， 所述络合剂处于有效浓度，以防止母体放射性核素仅在阳离子交换材料体积的一部分中浓缩，阳离子交换材料选自大孔树脂和具有交联性的树脂 率从1％到12％。 该方法适用于放射α粒子并特别用于放射治疗领域的放射性同位素发生器。

公开(公告)号：US20060198772A1

公开(公告)日：2006-09-07

申请号：US10548608

申请日：2004-03-05

申请人： Kamel Abbas ,  Christos Apostolidis ,  Willem Janssens ,  Hermann Stamm ,  Tuomo Nikula ,  Ramon Carlos-Marquez

发明人： Kamel Abbas ,  Christos Apostolidis ,  Willem Janssens ,  Hermann Stamm ,  Tuomo Nikula ,  Ramon Carlos-Marquez

IPC分类号： C01F13/00

CPC分类号： H05H6/00 ,  A61K51/02 ,  G21G1/10 ,  G21G4/08

摘要： A method for producing Ac-225 is presented, wherein Ac-225 is produced by bombardment of Ra-226 with deuterons accelerated in a cyclotron. The deuterons preferably have an incident energy of between 15 and 22 MeV. The method, which allows production of Ac-225 at high yields and purity levels, is particularly interesting in view of Bi-213 generation.

摘要翻译： 提出了一种生产Ac-225的方法，其中Ac-225是通过在回旋加速器中加速的氘核轰击Ra-226而产生的。 氘核优选具有15至22MeV的入射能量。 鉴于Bi-213生成，该方法以高产率和纯度水平生产Ac-225是特别有趣的。