公开(公告)号：US20230058982A1

公开(公告)日：2023-02-23

申请号：US17788998

申请日：2019-12-27

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Hitoshi KATADA ,  Kanako TATSUMI ,  Kanako ATSUMI ,  Shun SHIMIZU ,  Masaki KAMIMURA ,  Yasunori KOMORII ,  Yuji HORI ,  Tomoyuki IGAWA ,  Hiroki KAWAUCHI ,  Hiroaki SUSUMU

IPC分类号： C07K16/28 ,  C12N15/63 ,  A61P35/00

摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region and methods of producing and using the polypeptides.

公开(公告)号：US20240059774A1

公开(公告)日：2024-02-22

申请号：US18470185

申请日：2023-09-19

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Hitoshi KATADA ,  Kanako TATSUMI ,  Yutaka MATSUDA ,  Shun SHIMIZU ,  Masaki KAMIMURA ,  Yasunori KOMORI ,  Yuji HORI ,  Tomoyuki IGAWA ,  Hiroki KAWAUCHI ,  Hiroki HAYASHI ,  Hiroaki SUSUMU

IPC分类号： C07K16/28

CPC分类号： C07K16/2818 ,  A61K2039/505

摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.

公开(公告)号：US20240002510A2

公开(公告)日：2024-01-04

申请号：US17848983

申请日：2022-06-24

申请人： Chugai Seiyaku Kabushiki Kaisha ,  Osaka University

发明人： Hitoshi KATADA ,  Kanako TATSUMI ,  Yutaka MATSUDA ,  Shun SHIMIZU ,  Masaki KAMIMURA ,  Yasunori KOMORI ,  Yuji HORI ,  Tomoyuki IGAWA ,  Hiroki KAWAUCHI ,  Hiroki HAYASHI ,  Hiroaki SUSUMU ,  Shimon SAKAGUCHI

IPC分类号： C07K16/28

CPC分类号： C07K16/2818 ,  A61K2039/505

摘要： The present disclosure provides anti-CTLA-4 antibodies and methods of producing and using the antibodies. The present disclosure also provides nucleic acids encoding the anti-CTLA-4 antibodies and host cells containing the nucleic acids. Furthermore, the present disclosure provides polypeptides containing a variant Fc region containing amino acid alterations in a parent Fc region and methods of producing and using the polypeptides.