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1.发明授权公开(公告)号：US10738111B2
公开(公告)日：2020-08-11
申请号：US15963449
申请日：2018-04-26
发明人： Yoshinao Ruike , Taichi Kuramochi , Hiroyasu Muramatsu , Atsunori Ueyama , Tomoyuki Igawa , Hitoshi Katada , Yuji Hori
摘要： The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The anti-myostatin antibodies have uses that include treating a muscle wasting disease, reducing body fat accumulation, and increasing mass and strength of muscle tissue. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include suppressing the activation of immune cells; treating an immunological inflammatory disease, autoimmune disease, or viral infection; and increasing muscle mass and strength or reducing body fat accumulation.
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2.发明申请Anti-Myostatin Antibodies, Polypeptides Containing Variant Fc Regions, and Methods of Use 有权抗肌生成抑制素抗体，含有变体Fc区的多肽和使用方法公开(公告)号：US20160200807A1
公开(公告)日：2016-07-14
申请号：US14974488
申请日：2015-12-18
发明人： Yoshinao RUIKE , Taichi Kuramochi , Hiroyasu Muramatsu , Atsunori Ueyama , Tomoyuki Igawa , Hitoshi Katada , Yuji Hori
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N2510/02 , G01N33/6872 , G01N2333/495
摘要： The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The anti-myostatin antibodies have uses that include treating a muscle wasting disease, reducing body fat accumulation, and increasing mass and strength of muscle tissue. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include suppressing the activation of immune cells; treating an immunological inflammatory disease, autoimmune disease, or viral infection; and increasing muscle mass and strength or reducing body fat accumulation.
摘要翻译： 本公开提供抗肌生成抑制素抗体及其制备和使用方法。 还提供了编码抗肌生成抑制素抗体的核酸和包含核酸的宿主细胞。 抗肌生成抑制素抗体具有包括治疗肌肉消瘦疾病，减少体脂肪积聚以及增加肌肉组织的质量和强度的用途。 本公开还提供了含有变体Fc区的多肽及其制备和使用方法。 还提供了编码多肽的核酸和包含核酸的宿主细胞。 多肽具有包括抑制免疫细胞活化的用途; 治疗免疫性炎性疾病，自身免疫性疾病或病毒感染; 并增加肌肉质量和强度或减少身体脂肪积累。
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3.发明授权公开(公告)号：US10000560B2
公开(公告)日：2018-06-19
申请号：US14974488
申请日：2015-12-18
发明人： Yoshinao Ruike , Taichi Kuramochi , Hiroyasu Muramatsu , Atsunori Ueyama , Tomoyuki Igawa , Hitoshi Katada , Yuji Hori
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N2510/02 , G01N33/6872 , G01N2333/495
摘要： The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The anti-myostatin antibodies have uses that include treating a muscle wasting disease, reducing body fat accumulation, and increasing mass and strength of muscle tissue. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include suppressing the activation of immune cells; treating an immunological inflammatory disease, autoimmune disease, or viral infection; and increasing muscle mass and strength or reducing body fat accumulation.
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4.发明授权公开(公告)号：US11454633B2
公开(公告)日：2022-09-27
申请号：US16889066
申请日：2020-06-01
发明人： Yoshinao Ruike , Taichi Kuramochi , Hiroyasu Muramatsu , Atsunori Ueyama , Tomoyuki Igawa , Hitoshi Katada , Yuji Hori
摘要： The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The anti-myostatin antibodies have uses that include treating a muscle wasting disease, reducing body fat accumulation, and increasing mass and strength of muscle tissue. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include suppressing the activation of immune cells; treating an immunological inflammatory disease, autoimmune disease, or viral infection; and increasing muscle mass and strength or reducing body fat accumulation.
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