公开(公告)号：US5468286A

公开(公告)日：1995-11-21

申请号：US316664

申请日：1994-09-30

申请人： Chung Wai-Chiu ,  James J. Kasica

发明人： Chung Wai-Chiu ,  James J. Kasica

IPC分类号： A61K9/20 ,  C08B30/12 ,  C12P19/14 ,  C09D103/02 ,  C08L3/02

CPC分类号： C08B30/12 ,  A61K9/2059 ,  C12P19/14

摘要： A process for preparing a tablet excipient, comprising the steps:(a) enzymatically treating a starch containing greater than 90% amylopectin with an alpha-1,6-D-glucanohydrolase to debranch the starch and yield a mixture comprising a starch component selected from the group consisting of amylopectin, partially debranched amylopectin, and a combination thereof, and at least 20%, by weight, of a short chain amylose of from about 5 to 65 anhydroglucose units linked by alpha-1,4-D-glucoside bonds; and(b) drying the starch mixture,wherein the starch mixture is characterized by sufficient compressibility for use as an excipient, a binder, a binder-disintegrant, a binder-diluent, a filler or diluent, a moisture absorbent, a glidant, lubricant or flow agent, a surface gloss or hardness agent, or a combination thereof, in tablets.

摘要翻译： 一种制备片剂赋形剂的方法，包括以下步骤：（a）用α-1,6-D-葡聚糖水解酶酶解处理含有大于90％支链淀粉的淀粉，以将淀粉脱支并产生包含选自 由支链淀粉，部分脱支链的支链淀粉及其组合组成的组，以及至少20重量％的通过α-1,4-D-葡萄糖苷键连接的约5至65个脱水葡萄糖单元的短链直链淀粉; 和（b）干燥淀粉混合物，其中淀粉混合物的特征在于用作赋形剂的足够的压缩性，粘合剂，粘合剂 - 崩解剂，粘合剂 - 稀释剂，填充剂或稀释剂，吸湿剂，助流剂，润滑剂 或流动剂，表面光泽或硬度剂，或其组合。