公开(公告)号：US07592457B2

公开(公告)日：2009-09-22

申请号：US11242665

申请日：2005-10-04

申请人： Churlmin Seong ,  Nosang Park ,  Yungsik Jung ,  Jinil Choi ,  Wookyu Park ,  Heeyung Cho ,  Jaeyang Kong ,  Daeyoung Jung ,  Sunhee Kang ,  Sukjin Song ,  Kyungran Kwark

发明人： Churlmin Seong ,  Nosang Park ,  Yungsik Jung ,  Jinil Choi ,  Wookyu Park ,  Heeyung Cho ,  Jaeyang Kong ,  Daeyoung Jung ,  Sunhee Kang ,  Sukjin Song ,  Kyungran Kwark

IPC分类号： C07D215/38

CPC分类号： C07C233/55 ,  C07C235/38 ,  C07C237/20 ,  C07C271/44 ,  C07C275/42 ,  C07D215/22

摘要： The present invention relates to compounds of 3-aryl-3-methyl-quinoline-2,4-diones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of 3-aryl-3-methyl-quinoline-2,4-diones according to the present invention may be valuably used for treatment of a 5HT6 receptor relating disorders because of its excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors.

摘要翻译： 本发明涉及作为5HT6受体拮抗剂的3-芳基-3-甲基 - 喹啉-2,4-二酮的化合物，其制备方法和含有该化合物的药物组合物，用于治疗中枢神经系统疾病。 根据本发明的3-芳基-3-甲基 - 喹啉-2,4-二酮的化合物可以有价值地用于治疗5HT6受体相关疾病，因为其对5HT6受体具有优异的结合亲和力，并且对于 5HT6受体超过其他受体。

公开(公告)号：US20060084676A1

公开(公告)日：2006-04-20

申请号：US11242665

申请日：2005-10-04

申请人： Churlmin Seong ,  Nosang Park ,  Yungsik Jung ,  Jinil Choi ,  Wookyu Park ,  Heeyung Cho ,  Jaeyang Kong ,  Daeyoung Jung ,  Sunhee Kang ,  Sukjin Song ,  Kyungran Kwark

发明人： Churlmin Seong ,  Nosang Park ,  Yungsik Jung ,  Jinil Choi ,  Wookyu Park ,  Heeyung Cho ,  Jaeyang Kong ,  Daeyoung Jung ,  Sunhee Kang ,  Sukjin Song ,  Kyungran Kwark

IPC分类号： A61K31/4704 ,  C07D215/36

CPC分类号： C07C233/55 ,  C07C235/38 ,  C07C237/20 ,  C07C271/44 ,  C07C275/42 ,  C07D215/22

摘要： The present invention relates to compounds of 3-aryl-3-methyl-quinoline-2,4-diones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of 3-aryl-3-methyl-quinoline-2,4-diones according to the present invention may be valuably used for treatment of a 5HT6 receptor relating disorders because of its excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors.

摘要翻译： 本发明涉及作为5HT6受体拮抗剂的3-芳基-3-甲基 - 喹啉-2,4-二酮的化合物，其制备方法和含有该化合物的药物组合物，用于治疗中枢神经系统疾病。 根据本发明的3-芳基-3-甲基 - 喹啉-2,4-二酮的化合物可以有价值地用于治疗5HT6受体相关疾病，因为其对5HT6受体具有优异的结合亲和力，并且对于 5HT6受体超过其他受体。