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    Compositions for treating hyperproliferative vascular disorders and cancers
    2.
    发明授权
    Compositions for treating hyperproliferative vascular disorders and cancers 有权
    用于治疗过度增生性血管疾病和癌症的组合物

    公开(公告)号：US08106071B2

    公开(公告)日：2012-01-31

    申请号：US12528224

    申请日：2007-05-23

    申请人： Kwang Hoe Chung ,  Chwang Siek Pak ,  Sung Yu Hong ,  Soo Jung Kang ,  Young Doug Sohn ,  Jae Hoon Hwang ,  Eun Bok Choi ,  Gyu Hwan Yon ,  Hyeon Kyu Lee ,  Heui Cheol Yang

    发明人： Kwang Hoe Chung ,  Chwang Siek Pak ,  Sung Yu Hong ,  Soo Jung Kang ,  Young Doug Sohn ,  Jae Hoon Hwang ,  Eun Bok Choi ,  Gyu Hwan Yon ,  Hyeon Kyu Lee ,  Heui Cheol Yang

    IPC分类号： A01N43/42

    CPC分类号： A61K31/47

    摘要： The present invention relates to a method for treating or reducing the development of a hyperproliferative disorder, which comprises administering to a subject a composition, which comprises as an active ingredient the compound represented by the Formula 1: wherein R1, R2, R3, R4, R5, R6 and R7 independently represent hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl or alkylaryl; X and Y independently represent hydrogen, oxygen, or sulfur, bound to a carbon atom via a single or double bond; Z represents hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl, alkylaryl or —NH—R8; R8 represents hydrogen, halo, hydroxyl, cyano, amino, nitro, nitroso, carboxyl, C1-C12 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, C1-C6 alkylamino, C1-C6 alkoxy, aryl, heteroaryl, arylalkyl, arylalkenyl or alkylaryl; n is an integer of 0-3.

    摘要翻译： 本发明涉及一种治疗或减轻过度增殖性疾病发展的方法，其包括向受试者施用组合物，其包含作为活性成分的由式1表示的化合物：其中R1，R2，R3，R4， R5，R6和R7独立地表示氢，卤素，羟基，氰基，氨基，硝基，亚硝基，羧基，C1-C12烷基，C2-C6烯基，C3-C8环烷基，C5-C7环烯基，C1-C6烷基氨基，C1- C6烷氧基，芳基，杂芳基，芳基烷基，芳基烯基或烷基芳基; X和Y独立地表示通过单键或双键与碳原子结合的氢，氧或硫; Z代表氢，卤素，羟基，氰基，氨基，硝基，亚硝基，羧基，C1-C12烷基，C2-C6烯基，C3-C8环烷基，C5-C7环烯基，C1-C6烷基氨基，C1-C6烷氧基， 杂芳基，芳基烷基，芳基烯基，烷基芳基或-NH-R8; R8代表氢，卤素，羟基，氰基，氨基，硝基，亚硝基，羧基，C1-C12烷基，C2-C6烯基，C3-C8环烷基，C5-C7环烯基，C1-C6烷基氨基，C1-C6烷氧基， 杂芳基，芳基烷基，芳基烯基或烷基芳基; n为0-3的整数。