公开(公告)号：US20100240136A1

公开(公告)日：2010-09-23

申请号：US12785257

申请日：2010-05-21

申请人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

发明人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

IPC分类号： G01N33/86

CPC分类号： C12Q1/56 ,  G01N33/86 ,  Y10T436/11 ,  Y10T436/2575

摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

公开(公告)号：US07923256B2

公开(公告)日：2011-04-12

申请号：US12785257

申请日：2010-05-21

申请人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

发明人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

IPC分类号： G01N33/86

CPC分类号： C12Q1/56 ,  G01N33/86 ,  Y10T436/11 ,  Y10T436/2575

摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

摘要翻译： 本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。 与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。 还提供了用于凝血酶的人造底物，其作用导致凝块形成。 随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

公开(公告)号：US20100240067A1

公开(公告)日：2010-09-23

申请号：US12785191

申请日：2010-05-21

申请人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

发明人： Cindra A. Widrig Opalsky ,  David Opalsky ,  Andrzej MacZuszenko ,  Imants R. Lauks ,  Rhonda J. Cheadle

IPC分类号： G01N33/573

CPC分类号： C12Q1/56 ,  G01N33/86 ,  Y10T436/11 ,  Y10T436/2575

摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

摘要翻译： 本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。 与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。 还提供了用于凝血酶的人造底物，其作用导致凝块形成。 随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。