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公开(公告)号:US07495080B2
公开(公告)日:2009-02-24
申请号:US11551347
申请日:2006-10-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US08309692B2
公开(公告)日:2012-11-13
申请号:US13090316
申请日:2011-04-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
IPC分类号: C07K16/28 , A61K39/395 , C07K14/00
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20110287012A1
公开(公告)日:2011-11-24
申请号:US13090316
申请日:2011-04-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
IPC分类号: A61K39/395 , A61P43/00 , C07K16/18
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US07947474B2
公开(公告)日:2011-05-24
申请号:US11551322
申请日:2006-10-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 新的多肽,编码多肽的多核苷酸以及相关组合物和方法公开于zyctor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zyctor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US07521537B2
公开(公告)日:2009-04-21
申请号:US11551337
申请日:2006-10-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号:US07427494B2
公开(公告)日:2008-09-23
申请号:US11551328
申请日:2006-10-20
申请人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
发明人: Cindy A. Sprecher , Scott R. Presnell , Zeren Gao , Theodore E. Whitmore , Joseph L. Kuijper , Mark F. Maurer
CPC分类号: C07K14/715
摘要: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽,编码多肽的多核苷酸,以及相关的组合物和方法,用于zcytor17,一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血,淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上,可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20100266499A1
公开(公告)日:2010-10-21
申请号:US12432286
申请日:2009-04-29
申请人: Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人: Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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8.
公开(公告)号:US07494804B2
公开(公告)日:2009-02-24
申请号:US10351157
申请日:2003-01-21
申请人: Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人: Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽组合,编码多肽的多核苷酸以及相关组合物和方法,用于含有Zcytor17的多聚体或异二聚体细胞因子受体,其可用作新的细胞因子拮抗剂,并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ,淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法,其用途及其抗体。
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公开(公告)号:US20110318354A1
公开(公告)日:2011-12-29
申请号:US13085645
申请日:2011-04-13
申请人: Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人: Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽组合,编码多肽的多核苷酸以及相关组合物和方法,用于含有Zcytor17的多聚体或异二聚体细胞因子受体,其可用作新的细胞因子拮抗剂,并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ,淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法,其用途及其抗体。
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公开(公告)号:US20120264168A1
公开(公告)日:2012-10-18
申请号:US13405916
申请日:2012-02-27
申请人: Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人: Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译: 公开了新型多肽组合,编码多肽的多核苷酸以及相关组合物和方法,用于含有Zcytor17的多聚体或异二聚体细胞因子受体,其可用作新的细胞因子拮抗剂,并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ,淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法,其用途及其抗体。
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