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公开(公告)号：US20100266499A1
公开(公告)日：2010-10-21
申请号：US12432286
申请日：2009-04-29
申请人： Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US07494804B2
公开(公告)日：2009-02-24
申请号：US10351157
申请日：2003-01-21
申请人： Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Zeren Gao , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Scott R. Presnell , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20120264168A1
公开(公告)日：2012-10-18
申请号：US13405916
申请日：2012-02-27
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20100055101A1
公开(公告)日：2010-03-04
申请号：US12545770
申请日：2009-08-21
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61K38/16 , A61P29/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20090274694A1
公开(公告)日：2009-11-05
申请号：US12484019
申请日：2009-06-12
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： A61K39/395 , C12N9/96 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20110318354A1
公开(公告)日：2011-12-29
申请号：US13085645
申请日：2011-04-13
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US07064186B2
公开(公告)日：2006-06-20
申请号：US10352554
申请日：2003-01-21
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。
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8.发明授权Method for expanding hematopoietic cells using cytokine zalpha11 ligand 有权使用细胞因子zalpha11配体扩增造血细胞的方法公开(公告)号：US07829075B2
公开(公告)日：2010-11-09
申请号：US11551127
申请日：2006-10-19
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US07611699B2
公开(公告)日：2009-11-03
申请号：US11551349
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US07592425B2
公开(公告)日：2009-09-22
申请号：US11551362
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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